UniProt Accession

 FCF1_YEAST; Q05498; D6VSX1 

Genbank Protein ID

 U51032; AY557728; BK006938 

Genbank Nucleotide ID

 AAB64775.1; AAS56054.1; DAA12181.1 

Protein Name

 rRNA-processing protein FCF1 

Protein Synonyms/Alias

 FAF1-copurifying factor 1 

Gene Name

 FCF1 

Gene Synonyms/Alias

 YDR339C; D9651.9 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
161	ATNDAGLKQRIRKIP	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Required for the early cleavage steps of 35S rRNA at the A(0), A(1), and A(2) sites. 

Sequence Annotation

 DOMAIN 63 162 PINc.  

Keyword

 Complete proteome; Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 189 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0032040; C:small-subunit processome; IDA:SGD.
 GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. 

Interpro

 IPR006984; DUF652.
 IPR006596; PINc_nuc-bd. 

Pfam

 PF04900; Fcf1 

SMART

 SM00670; PINc 

PROSITE

  

PRINTS