CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038380
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Alpha-actinin-4 
Protein Synonyms/Alias
  
Gene Name
 Actn4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
284TAANRICKVLAVNQEacetylation[1]
324LEDRVPQKTIQEMQQacetylation[1, 2]
332TIQEMQQKLEDFRDYubiquitination[3]
433HEAWTDGKEAMLKQRubiquitination[3]
451TATLSDIKALIRKHEubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 518 AA 
Protein Sequence
MVDYHAANQA YQYGPNSGGG NGAGGGGSMG DYMAQEDDWD RDLLLDPAWE KQQRKTFTAW 60
CNSHLRKAGT QIENIDEDFR DGLKLMLLLE VISGERLPKP ERGKMRVHKI NNVNKALDFI 120
ASKGVKLVSI GAEEIVDGNA KMTLGMIWTI ILRFAIQDIS VEETSAKEGL LLWCQRKTAP 180
YKNVNVQNFH ISWKDGLAFN ALIHRHRPEL IEYDKLRKDD PVTNLNNAFE VAEKYLDIPK 240
MLDAEDIVGT LRPDEKAIMT YVSCFYHAFS GAQKAETAAN RICKVLAVNQ ENEHLMEDYE 300
RLASDLLEWI RRTIPWLEDR VPQKTIQEMQ QKLEDFRDYR RVHKPPKVQE KCQLEINFNT 360
LQTKLRLSNR PAFMPSEGRM VSDINNGWQH LEQAEKGYEE WLLNEIRRLE RLDHLAEKFR 420
QKASIHEAWT DGKEAMLKQR DYETATLSDI KALIRKHEAF ESDLAAHQDR VEQIAAIAQE 480
LNELDYYDSH NVNTRCQKIC DQWDNLGSLT HSRREALE 518 
Gene Ontology
 GO:0030863; C:cortical cytoskeleton; IDA:MGI.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0051015; F:actin filament binding; IDA:MGI.
 GO:0051764; P:actin crosslink formation; IEA:InterPro.
 GO:0051017; P:actin filament bundle assembly; IEA:InterPro. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR026921; Alpha-actinin.
 IPR001715; CH-domain.
 IPR018159; Spectrin/alpha-actinin.
 IPR002017; Spectrin_repeat. 
Pfam
 PF00307; CH
 PF00435; Spectrin 
SMART
 SM00033; CH
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH 
PRINTS