UniProt Accession

 ST1D1_MOUSE; Q3UZZ6; O35401; Q6NZD1; Q9R2C2 

Genbank Protein ID

 AF026073; U32371; AK133530; AC158917; BC066190 

Genbank Nucleotide ID

 AAC69919.1; AAC99889.1; BAE21709.1; AAH66190.1 

Protein Name

 Sulfotransferase 1 family member D1 

Protein Synonyms/Alias

 ST1D1; Amine N-sulfotransferase; SULT-N; Dopamine sulfotransferase Sult1d1; Tyrosine-ester sulfotransferase 

Gene Name

 Sult1d1 

Gene Synonyms/Alias

 St1d1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
4	****MDNKLDVFRRE	ubiquitination	[1]
106	MPSPRIVKTHLPVQL	ubiquitination	[1]
120	LLPSSFWKNDCKIIY	ubiquitination	[1]
213	KILKFLEKDIPEEIL	ubiquitination	[1]
233	HSSFSVMKENPSANY	ubiquitination	[1]
245	ANYTTMMKEEMDHSV	ubiquitination	[1]
258	SVSPFMRKGISGDWK	ubiquitination	[1]
275	FTVAQYEKFEEDYVK	ubiquitination	[1]
282	KFEEDYVKKMEDSTL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Sulfotransferase with broad substrate specificity that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, such as dopamine, prostaglandins, leukotriene E4, drugs and xenobiotic compounds. Has sulfotransferase activity towards p-nitrophenol, 2- naphthylamine and minoxidil (in vitro). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. 

Sequence Annotation

 NP_BIND 48 53 PAPS.
 NP_BIND 227 232 PAPS.
 NP_BIND 257 259 PAPS.
 REGION 106 108 Substrate binding.
 ACT_SITE 108 108 Proton acceptor (Probable).
 BINDING 81 81 Substrate.
 BINDING 130 130 PAPS.
 BINDING 138 138 PAPS.
 BINDING 142 142 Substrate.
 BINDING 193 193 PAPS.  

Keyword

 3D-structure; Catecholamine metabolism; Complete proteome; Cytoplasm; Lipid metabolism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004062; F:aryl sulfotransferase activity; IDA:MGI.
 GO:0006584; P:catecholamine metabolic process; IEA:UniProtKB-KW.
 GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
 GO:0000103; P:sulfate assimilation; IDA:MGI. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR000863; Sulfotransferase_dom. 

Pfam

 PF00685; Sulfotransfer_1 

SMART

  

PROSITE

  

PRINTS