CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011789
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosome biogenesis protein MAK21 
Protein Synonyms/Alias
 Maintenance of killer protein 21; Nucleolar complex protein 1 
Gene Name
 MAK21 
Gene Synonyms/Alias
 NOC1; YDR060W; D4237; YD9609.14 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
106NDLQNFMKNVGFDQHacetylation[1]
244LSKEQIEKLFERGKQacetylation[1]
419LLRLGVNKIGDIDSKubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Required for 60S ribosomal subunit synthesis. 
Sequence Annotation
 MOD_RES 62 62 Phosphoserine.
 MOD_RES 73 73 Phosphoserine.
 MOD_RES 80 80 Phosphoserine.
 MOD_RES 275 275 Phosphoserine.
 MOD_RES 708 708 Phosphotyrosine.
 MOD_RES 710 710 Phosphoserine.
 MOD_RES 874 874 Phosphoserine.
 MOD_RES 878 878 Phosphoserine.
 MOD_RES 977 977 Phosphoserine.
 MOD_RES 978 978 Phosphoserine.
 MOD_RES 1024 1024 Phosphoserine.  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1025 AA 
Protein Sequence
MSENNGNPLD LSSLRNKISS KLRDNNSKKA KKTHKGKDVK ASSNSKKVNE DIRREALALG 60
ASEEDLKLIQ GLSDDDDAKS EQEFDAVADE DADDKGFKND LQNFMKNVGF DQHKLEDVDD 120
DDIEEESTSS KESKIPAQEK EHAQSNIASS TIEKTSQESI DNGSEQEENT VEEANLSSDQ 180
EPESESAEKE KKEEKDGGLI TQTTIISSDK LIIPYDKPWY EIPLDPQVGQ NDDVEELSKE 240
QIEKLFERGK QTLEADNQTY YEEFTKDSSQ AKFMSQILSD GTLNDKISAV TLLIQDSPLH 300
NTKSLETLVS YCGKKSRNSA LQSLNALKDL FLNGLLPNRK LRYFKNQPGL SMMLNKKTLA 360
IFYFEDYLKK LFFRVLEVLE VLSHDPIIHV RLQILNHVFD LLTNQPEQEF NLLRLGVNKI 420
GDIDSKVSSK ASYLLLKLEQ AHPNMKSIVI DAIVDIALRP NADYHTTYYS VITLNQTILK 480
RSEDSVANKL VKTYFTLFEK FLINTDKDNT NGVVKSNSKS YEEKRKKNFK KGKHGGKSVK 540
IEKTENEVLD EKNSKLFSAL LTGINRAFPF AQIPASVYEV HMETLFKITH SSNFNTSIQA 600
LVLINQVTVK AKLNSDRYYR TLYESLFDPR LVNSSKQGIY LNLLYKSLKQ DALNVERVEA 660
FVKRILQVCS HWLNVGTITG FFFLLIQLAK TVPQIKNLLT NTPVDYEYES DAEEEQGDKD 720
IKRKEYDGRK RDPKFANAEK SSLWEINNFI NHFHPTVKTY ANAYVTGETE QIAKPDLGLF 780
TLSHFLDRFV YRSAKQTNTA RGTSIMQPLF SGSRVNDSVL VKASDIMHDQ GPVNTEDWLT 840
KKVEDIKPED KFFYQYFTTK KTADGKGKKS NKASNFDSDD EMDENEIWSA LVKSRPDVED 900
DSDDSELDFA EDDFSDSTSD DEPKLDAIDD EDAKSEGSQE SDQEEGLDED IFYSFDGEQD 960
NSDKKRSFAE SSEEDESSEE EKEEEENKEV SAKRAKKKQR KNMLKSLPVF ASADDYAQYL 1020
DQDSD 1025 
Gene Ontology
 GO:0030690; C:Noc1p-Noc2p complex; IPI:SGD.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0000027; P:ribosomal large subunit assembly; IMP:SGD. 
Interpro
 IPR016024; ARM-type_fold.
 IPR005612; CCAAT-binding_factor. 
Pfam
 PF03914; CBF 
SMART
  
PROSITE
  
PRINTS