UniProt Accession

 TRAM1_HUMAN; Q15629 

Genbank Protein ID

 X63679; BC000687; BC037738 

Genbank Nucleotide ID

 CAA45218.1; AAH00687.1; AAH37738.1 

Protein Name

 Translocating chain-associated membrane protein 1 

Protein Synonyms/Alias

  

Gene Name

 TRAM1 

Gene Synonyms/Alias

 TRAM 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
283	LARAENQKLDFSTGN	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Stimulatory or required for the translocation of secretory proteins across the ER membrane. 

Sequence Annotation

 DOMAIN 117 326 TLC.
 MOD_RES 365 365 Phosphoserine.
 CARBOHYD 56 56 N-linked (GlcNAc...) (Probable).  

Keyword

 Complete proteome; Endoplasmic reticulum; Glycoprotein; Host-virus interaction; Membrane; Phosphoprotein; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 374 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; TAS:ProtInc.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006412; P:translation; TAS:Reactome.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR006634; TLC-dom.
 IPR013599; TRAM1.
 IPR016447; Translocation_assoc_membrane. 

Pfam

 PF08390; TRAM1
 PF03798; TRAM_LAG1_CLN8 

SMART

 SM00724; TLC 

PROSITE

 PS50922; TLC 

PRINTS