CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039843
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Prefoldin subunit 3 
Protein Synonyms/Alias
  
Gene Name
 VBP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
54KLDEQYQKYKFMELNacetylation[1]
54KLDEQYQKYKFMELNubiquitination[2, 3, 4]
56DEQYQKYKFMELNLAubiquitination[2, 3]
65MELNLAQKKRRLKGQubiquitination[2, 4]
66ELNLAQKKRRLKGQIubiquitination[3]
77KGQIPEIKQTLEILKubiquitination[2, 3]
84KQTLEILKYMQKKKEubiquitination[2, 3]
148KNLSTATKNLDSLEEubiquitination[5]
180RVYNWDVKRRNKDDSubiquitination[2, 3]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 192 AA 
Protein Sequence
MAPQPMIHTQ QGLRTSSPST PSPEHQEDVD SFMKQPGNET ADTVLKKLDE QYQKYKFMEL 60
NLAQKKRRLK GQIPEIKQTL EILKYMQKKK ESTNSMETRF LLADNLYCKA SVPPTDKMCL 120
WLGANVMLEY DIDEAQALLE KNLSTATKNL DSLEEDLDFL RDQFTTTEVN MARVYNWDVK 180
RRNKDDSTKN KA 192 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0016272; C:prefoldin complex; IEA:InterPro.
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR009053; Prefoldin.
 IPR016655; Prefoldin_su-3.
 IPR004127; Prefoldin_subunit. 
Pfam
 PF02996; Prefoldin 
SMART
  
PROSITE
  
PRINTS