CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020947
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 
Protein Synonyms/Alias
 BAI1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate 
Gene Name
 Baiap2l1 
Gene Synonyms/Alias
 Irtks 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
39NLGKNYEKAVNAMILubiquitination[1]
106DIIHELEKKTELDVKacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity). 
Sequence Annotation
 DOMAIN 1 249 IMD.
 DOMAIN 340 403 SH3.
 REGION 486 514 Binds F-actin (By similarity).
 MOD_RES 248 248 Phosphothreonine (By similarity).
 MOD_RES 257 257 Phosphothreonine (By similarity).
 MOD_RES 261 261 Phosphoserine.
 MOD_RES 281 281 Phosphoserine (By similarity).
 MOD_RES 330 330 Phosphoserine.
 MOD_RES 332 332 Phosphoserine.
 MOD_RES 411 411 Phosphothreonine (By similarity).  
Keyword
 3D-structure; Actin-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 514 AA 
Protein Sequence
MSRGPEEVNR LTENTYRNVM EQFNPGLRNL INLGKNYEKA VNAMILAGKA YYDGVAKIGE 60
IATGSPVSTE LGHVLIEISS THKKLNETLD ENFKKFHKDI IHELEKKTEL DVKYMNATLK 120
RYQAEHRNKL DSLEKSQAEL KKIRRKSQGG RNALKYEHKE IEYVETVTSR QSEIQKFIAD 180
GCKEALLEEK RRFCFLVDKH CSFASHIHYY HMQSAELLNS KLPRWQETCC DATKVPEKIM 240
NMIEEIKTPI STPVSGTPQP SPMIERSKMI GKDYDTLSKY SPKMPPAPSV KAYTSPLIDM 300
FNNPATAAQS SEKTNNSTAN TGEDPSLQRS VSVATGLNMM KKQKVKTIFP HTAGNNKTLL 360
SFAQGDVLTL LIPEEKDGWL YGEHDTTKAR GWFPSSYTKL LEENEAMSVP TPSPAPVRSI 420
STVDLTEKSS VVIPPPDYLE CLSMGATSDK KAGAPKVPSA STFRAPVSRP DATSTSPSDA 480
NGTAKPPFLS GENPFATVKL RPTVTNDRSA PIIR 514 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0030054; C:cell junction; IEA:Compara.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0070064; F:proline-rich region binding; ISS:UniProtKB.
 GO:0046847; P:filopodium assembly; IEA:InterPro.
 GO:2000251; P:positive regulation of actin cytoskeleton reorganization; ISS:UniProtKB.
 GO:0030838; P:positive regulation of actin filament polymerization; ISS:UniProtKB.
 GO:0009617; P:response to bacterium; ISS:UniProtKB.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR013606; IRSp53/MIM_homology_IMD.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF08397; IMD
 PF07653; SH3_2 
SMART
 SM00326; SH3 
PROSITE
 PS51338; IMD
 PS50002; SH3 
PRINTS