UniProt Accession

 EF1G1_YEAST; P29547; D6W3W6; Q9URC6 

Genbank Protein ID

 L01879; X67917; U44030; BK006949 

Genbank Nucleotide ID

 AAA16892.1; CAA48116.1; AAB68173.1; DAA11382.1 

Protein Name

 Elongation factor 1-gamma 1 

Protein Synonyms/Alias

 EF-1-gamma 1; Calcium and membrane-binding protein 1; Calcium phospholipid-binding protein; CPBP; Eukaryotic elongation factor 1Bgamma 1; eEF1Bgamma 1; Translation elongation factor 1B gamma 1 

Gene Name

 CAM1 

Gene Synonyms/Alias

 TEF3; YPL048W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
29	KALKLDVKVVTPDAA	acetylation	[1]
127	GGAPYNKKSVDSAMD	acetylation	[1]
202	VRASPFLKDEYKDFK	acetylation	[1]
206	PFLKDEYKDFKFADK	acetylation	[1]
213	KDFKFADKPLSPPQK	acetylation	[1]
272	TFVLDDWKRKYSNED	acetylation	[1]
412	PKEIVDGKVLK****	acetylation	[1]
412	PKEIVDGKVLK****	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Subunit of the eukaryotic elongation factor 1 complex (eEF1). Probably plays a role in anchoring the complex to other cellular components. May be involved in transcriptional regulation of MXR1. 

Sequence Annotation

 DOMAIN 1 78 GST N-terminal.
 DOMAIN 89 215 GST C-terminal.
 DOMAIN 254 415 EF-1-gamma C-terminal.
 MOD_RES 32 32 Phosphothreonine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Elongation factor; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 415 AA 

Protein Sequence

Gene Ontology

 GO:0005853; C:eukaryotic translation elongation factor 1 complex; IEA:InterPro.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005509; F:calcium ion binding; IDA:SGD.
 GO:0005543; F:phospholipid binding; IDA:SGD.
 GO:0003713; F:transcription coactivator activity; IMP:SGD.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0042254; P:ribosome biogenesis; IGI:SGD. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR004046; GST_C.
 IPR012336; Thioredoxin-like_fold.
 IPR001662; Transl_elong_EF1_G_con. 

Pfam

 PF00647; EF1G
 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50040; EF1G_C
 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS