CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008399
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Caveolin-3 
Protein Synonyms/Alias
 M-caveolin 
Gene Name
 Cav3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
15DLEARIIKDIHCKEIubiquitination[1]
30DLVNRDPKNINEDIVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. 
Sequence Annotation
 REGION 64 114 Required for interaction with DAG1 (By
 CROSSLNK 38 38 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Cell membrane; Complete proteome; Golgi apparatus; Isopeptide bond; Membrane; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 151 AA 
Protein Sequence
MMTEEHTDLE ARIIKDIHCK EIDLVNRDPK NINEDIVKVD FEDVIAEPEG TYSFDGVWKV 60
SFTTFTVSKY WCYRLLSTLL GVPLALLWGF LFACISFCHI WAVVPCIKSY LIEIQCISHI 120
YSLCIRTFCN PLFAALGQVC SNIKVVLRRE G 151 
Gene Ontology
 GO:0005901; C:caveola; IDA:BHF-UCL.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0016010; C:dystrophin-associated glycoprotein complex; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; ISO:MGI.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0031594; C:neuromuscular junction; IEA:Compara.
 GO:0030315; C:T-tubule; IDA:MGI.
 GO:0031982; C:vesicle; IEA:Compara.
 GO:0043014; F:alpha-tubulin binding; IDA:MGI.
 GO:0005246; F:calcium channel regulator activity; IEA:Compara.
 GO:0017080; F:sodium channel regulator activity; IEA:Compara.
 GO:0007015; P:actin filament organization; IMP:MGI.
 GO:0055013; P:cardiac muscle cell development; IMP:MGI.
 GO:0070836; P:caveola assembly; IMP:MGI.
 GO:0016049; P:cell growth; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IMP:MGI.
 GO:0031122; P:cytoplasmic microtubule organization; IMP:MGI.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara.
 GO:0006897; P:endocytosis; IMP:MGI.
 GO:0090002; P:establishment of protein localization to plasma membrane; IMP:MGI.
 GO:0042593; P:glucose homeostasis; IMP:MGI.
 GO:0060347; P:heart trabecula formation; IMP:MGI.
 GO:0046716; P:muscle cell homeostasis; IMP:MGI.
 GO:0007520; P:myoblast fusion; IMP:MGI.
 GO:0051926; P:negative regulation of calcium ion transport; IMP:MGI.
 GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IMP:MGI.
 GO:0061052; P:negative regulation of cell growth involved in cardiac muscle cell development; IEA:Compara.
 GO:0045792; P:negative regulation of cell size; IEA:Compara.
 GO:0043407; P:negative regulation of MAP kinase activity; IEA:Compara.
 GO:0043409; P:negative regulation of MAPK cascade; IMP:MGI.
 GO:0051001; P:negative regulation of nitric-oxide synthase activity; IMP:MGI.
 GO:0006469; P:negative regulation of protein kinase activity; IMP:MGI.
 GO:0060299; P:negative regulation of sarcomere organization; IEA:Compara.
 GO:0051647; P:nucleus localization; IMP:MGI.
 GO:0001778; P:plasma membrane repair; IMP:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0031116; P:positive regulation of microtubule polymerization; IEA:Compara.
 GO:0010831; P:positive regulation of myotube differentiation; IMP:MGI.
 GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IMP:MGI.
 GO:0090279; P:regulation of calcium ion import; IEA:Compara.
 GO:1901019; P:regulation of calcium ion transmembrane transporter activity; IEA:Compara.
 GO:0055117; P:regulation of cardiac muscle contraction; IEA:Compara.
 GO:0002027; P:regulation of heart rate; IEA:Compara.
 GO:1900825; P:regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; IEA:Compara.
 GO:0042391; P:regulation of membrane potential; IGI:MGI.
 GO:0051394; P:regulation of nerve growth factor receptor activity; IEA:Compara.
 GO:1900744; P:regulation of p38MAPK cascade; IMP:MGI.
 GO:0051896; P:regulation of protein kinase B signaling cascade; IMP:MGI.
 GO:0038009; P:regulation of signal transduction by receptor internalization; IEA:Compara.
 GO:0014819; P:regulation of skeletal muscle contraction; IEA:Compara.
 GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IEA:Compara.
 GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IMP:MGI.
 GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IEA:Compara.
 GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Compara.
 GO:0006641; P:triglyceride metabolic process; IMP:MGI. 
Interpro
 IPR001612; Caveolin.
 IPR018361; Caveolin_CS. 
Pfam
 PF01146; Caveolin 
SMART
  
PROSITE
 PS01210; CAVEOLIN 
PRINTS