| Tag | Content |
|---|
| CPLM ID | CPLM-016513 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vesicular glutamate transporter 2 |
Protein Synonyms/Alias | VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6 |
Gene Name | Slc17a6 |
Gene Synonyms/Alias | Dnpi; Vglut2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 22 | GIKNFAGKSLGQIYR | ubiquitination | [1] | | 298 | NLLGAMEKFKTPWRK | ubiquitination | [1] | | 561 | WPNGWEKKEEFVQEG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. |
Sequence Annotation | MOD_RES 195 195 Phosphotyrosine.
CARBOHYD 100 100 N-linked (GlcNAc...) (Potential).
CARBOHYD 101 101 N-linked (GlcNAc...) (Potential).
CARBOHYD 470 470 N-linked (GlcNAc...) (Potential). |
Keyword | Cell junction; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Ion transport; Membrane; Neurotransmitter transport; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Synapse; Synaptosome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 582 AA |
Protein Sequence | MESVKQRILA PGKEGIKNFA GKSLGQIYRV LEKKQDNRET IELTEDGKPL EVPEKKAPLC 60
DCTCFGLPRR YIIAIMSGLG FCISFGIRCN LGVAIVDMVN NSTIHRGGKV IKEKAKFNWD 120
PETVGMIHGS FFWGYIITQI PGGYIASRLA ANRVFGAAIL LTSTLNMLIP SAARVHYGCV 180
IFVRILQGLV EGVTYPACHG IWSKWAPPLE RSRLATTSFC GSYAGAVIAM PLAGILVQYT 240
GWSSVFYVYG SFGMVWYMFW LLVSYESPAK HPTITDEERR YIEESIGESA NLLGAMEKFK 300
TPWRKFFTSM PVYAIIVANF CRSWTFYLLL ISQPAYFEEV FGFEISKVGM LSAVPHLVMT 360
IIVPIGGQIA DFLRSKQILS TTTVRKIMNC GGFGMEATLL LVVGYSHTRG VAISFLVLAV 420
GFSGFAISGF NVNHLDIAPR YASILMGISD GVGTLSGMVC PIIVGAMTKN KSREEWQYVF 480
LIAALVHYGG VIFYALFASG EKQPWADPEE TSEEKCGFIH EDELDEETGD ITQNYINYGT 540
TKSYGATSQE NGGWPNGWEK KEEFVQEGAQ DAYTYKDRDD YS 582 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell. GO:0008021; C:synaptic vesicle; IDA:MGI. GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell. GO:0005313; F:L-glutamate transmembrane transporter activity; IDA:MGI. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. GO:0001504; P:neurotransmitter uptake; IDA:MGI. GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. |
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PROSITE | |
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