| Tag | Content |
|---|
| CPLM ID | CPLM-016036 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin-protein ligase E3C |
Protein Synonyms/Alias | |
Gene Name | Ube3c |
Gene Synonyms/Alias | Kiaa0010; Kiaa10 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 63 | IRGYRDRKQQYFIQR | ubiquitination | [1] | | 638 | QEDIKADKVTQLYVP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo (By similarity). |
Sequence Annotation | DOMAIN 45 74 IQ.
DOMAIN 744 1083 HECT.
REGION 1 60 Cis-determinant of acceptor ubiquitin-
ACT_SITE 1051 1051 Glycyl thioester intermediate (By |
Keyword | Complete proteome; Ligase; Nucleus; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1083 AA |
Protein Sequence | MFSFEGDFKT RPKVSLGGAS RKEEKASLLH RTQEERRKRE EERRRLKNAV IIQSFIRGYR 60
DRKQQYFIQR SAFDQCTDSA QPGGTFCLAD GPNLTLLVRQ LLFFYKQSED SKRLIWLYQN 120
LIKHSSLFVK QLDGSERLTC LFQIKRLMSL CCRLLQNCSD DSLNVALPMR MLEVFTSENT 180
YLPVLQDSSY VVSVIEQILH YMVHSGYYRS LYLLINSKLP SSIEYSDLSR VPIAKILLEN 240
VLKPLHFTYS SCPEASRHQV FSAFTEEFLG APFTDQIFHF VIPAFADAQT VFPYEPFLNA 300
LLLLESQSSK RCSGVPWLFY FVLTVGENYL GALSEDGLLV YLRVLQTFLS QLPASPTGTG 360
CPDSTSDSED DNEETDQPNS PEDGRVSAPY ITEECLRKLD TKQQTNTLLN LVWRDSASEE 420
VFTRMASICH TLMVQHRMMV PKVRLLYSLA FNARFLRHLW FLISSMTTQM ITGSMVPLLQ 480
LISRGSPMSF EDSSRIIPLF YLFSSLFSHS LISIHDNEFF GDPIEVVGQR QSSMMPFTLE 540
ELILLSRCLR DACLGIIKLA YPETKPEVRE EYVTAFQSIG VTTNSEMQQC IQMEQKRWVQ 600
LFKVITNLVK MLKSRDTRRN FCPPNHWLSE QEDIKADKVT QLYVPASRHV WRFRRMGRIG 660
PLQSTLEVGL ESLPLSVSEE RQLAILTELP FVVPFEERVK IFQRLIYADK QEVQGDGPFL 720
DGINVTIRRN YIYEDAYDKL SPENEPDLKK RIRVHLLNAH GLDEAGIDGG GIFREFLNEL 780
LKSGFNPNQG FFKTTNEGLL YPNPAAQMLV GDSFARHYYF LGRMLGKALY ENMLVELPFA 840
GFFLSKLLGT SADVDIHHLA SLDPEVYRNL LFLKSYEEDV EELGLNFTVV NNDLGEAQVV 900
ELKFGGKDIP VTGANRIAYI HLVADYRLNK QIRPHCLAFR QGLANVVSLE WLRMFDQQEI 960
QVLISGAQVP VSLEDLKSFT NYSGGYSADH PVIKIFWRVV EGFTDEEKRK LLKFVTSCSR 1020
PPLLGFKELY PAFCIHNGGS DLERLPTAST CMNLLKLPEF YDEALLRSKL LYAIECAAGF 1080
ELS 1083 |
Gene Ontology | GO:0005737; C:cytoplasm; IBA:RefGenome. GO:0005634; C:nucleus; IBA:RefGenome. GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. GO:0000209; P:protein polyubiquitination; IEA:Compara. GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |