UniProt Accession

 RL5_YEAST; P26321; D6W3N6 

Genbank Protein ID

 M65056; M94864; L01796; U43703; BK006949 

Genbank Nucleotide ID

 AAA35234.1; AAA35236.1; AAA34979.1; AAB68228.1; DAA11302.1 

Protein Name

 60S ribosomal protein L5 

Protein Synonyms/Alias

 L1; L1a; Ribosomal 5S RNA-binding protein; YL3 

Gene Name

 RPL5 

Gene Synonyms/Alias

 RPL1; RPL1A; YPL131W; LPI14W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
8	MAFQKDAKSSAYSSR	ubiquitination	[1]
27	FRRRREGKTDYYQRK	acetylation	[2]
43	LVTQHKAKYNTPKYR	ubiquitination	[1]
58	LVVRFTNKDIICQII	ubiquitination	[1]
112	IARRTLQKLGLDETY	acetylation	[2]
112	IARRTLQKLGLDETY	ubiquitination	[1]
164	ARVFGALKGASDGGL	acetylation	[2]
164	ARVFGALKGASDGGL	ubiquitination	[1, 3]
254	IRADPAFKPTEKKFT	acetylation	[2]
262	PTEKKFTKEQYAAES	acetylation	[2]
289	RAARVAAKIAALAGQ	acetylation	[2]
289	RAARVAAKIAALAGQ	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 Binds 5S RNA and is required for 60S subunit assembly. 

Sequence Annotation

 MOD_RES 167 167 Phosphoserine.
 MOD_RES 176 176 Phosphoserine.
 MOD_RES 235 235 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 297 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; TAS:SGD.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008097; F:5S rRNA binding; IDA:SGD.
 GO:0003735; F:structural constituent of ribosome; TAS:SGD.
 GO:0002181; P:cytoplasmic translation; TAS:SGD.
 GO:0000027; P:ribosomal large subunit assembly; IMP:SGD. 

Interpro

 IPR005485; Rbsml_L5_euk/L18_arc.
 IPR025607; Rbsml_L5e/L18P_C.
 IPR005484; Ribosomal_L18/L5. 

Pfam

 PF14204; Ribosomal_L18_c
 PF00861; Ribosomal_L18p 

SMART

  

PROSITE

  

PRINTS

 PR00058; RIBOSOMALL5.