CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012823
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glutamine and serine-rich protein 1 
Protein Synonyms/Alias
  
Gene Name
 QSER1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
281PPSTTKIKSCSTEQPubiquitination[1, 2]
368YRSSKVEKLPPLYKTubiquitination[2]
549PKSYAERKLDSDVYPubiquitination[1, 2]
598NAQESTYKVSKADDRubiquitination[1, 2]
674PQIRLNTKDLKQQHPubiquitination[1, 2]
677RLNTKDLKQQHPLILubiquitination[1, 2]
803MDLSESSKPLQQHLTacetylation[3, 4]
803MDLSESSKPLQQHLTubiquitination[2]
978EQSSGPFKKQSATNLacetylation[4]
1162DFLKSGPKQQFSTLAubiquitination[1]
1583LLLPHMKKIDGMLNDubiquitination[5]
1654RTSKTTTKSAQEFAVubiquitination[5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
 MOD_RES 949 949 Phosphothreonine.
 MOD_RES 1211 1211 Phosphoserine.
 MOD_RES 1230 1230 Phosphoserine.
 MOD_RES 1231 1231 Phosphoserine.
 MOD_RES 1239 1239 Phosphoserine.
 MOD_RES 1341 1341 Phosphothreonine.
 MOD_RES 1348 1348 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1735 AA 
Protein Sequence
MNFLSTAESR TAQAAASGTT LLPQFRAPSW QTGMHSSAAT ELFATGPLPS TGTLPPSLSA 60
YQHPTTFSNR NFATTSPLVL QDSTFNTTSN GILSHHDPLL QIKTSQGTVP TALAFERLGS 120
SVLSNSIPPQ SSTYRSAQES APHLLQPQFS LLPSALGGSQ QTPQAYSSTL FTSSTASIER 180
ALLRECSVIK HHQRPSGTQS IQAQLTGSQH SLHSYLSNSS VVNFQETTRQ SSLSCSPIGD 240
STQVSNGGLQ QKTSQVSVEL AQSYSSAIPS SGYPPSTTKI KSCSTEQPLT STKTPKPQSI 300
IPPVQTLSYS KPLHNQSSVI SGQAQIYSTA QLPSLLSVSQ SQNYGLVQPH NVPSIVHSQV 360
YRSSKVEKLP PLYKTLTFSG SSQTVTPENQ TLNYSSNQQE VLSSVTNENY PAQTRDLSSV 420
SQSQSYSSGH SQGLSPVSQT QVSYSSQSQV LSVVSLSESY ASGESLTLTA PSLSYSSASR 480
AQNLPDSSPT QNYISMHSSQ NVQTQESSSP QSQKFLPAVQ SSSFASSTHC QTLQNNITSP 540
DPKSYAERKL DSDVYPSSKQ EDGFPMQELQ VLQPQASLES STQRLSDGEI NAQESTYKVS 600
KADDRYSQSV IRSNSRLEDQ VIGVALQASK KEESVVGSVT QLNQQIGQVN NAATLDLKNS 660
TNLIQTPQIR LNTKDLKQQH PLILKVHESK VQEQHDQIIN ASSQIQIPNH ALGHGHQASL 720
PNTQVLLDSA CDLQILQQSI LQAGLGQVKA SLQAQRVQSP QQIVHPFLQM EGHVIQSNGD 780
HSQQQLHPQN SEVMKMDLSE SSKPLQQHLT TKGHFSETNQ HDSKNQFVSL GSMCFPEAVL 840
LSDERNILSN VDDILAATAA ACGVTPTDFS KSTSNETMQA VEDGDSKSHF QQSLDVRHVT 900
SDFNSMTATV GKPQNINDTS LNGNQVTVNL SPVPALQSKM TLDQQHIETP GQNIPTKVTS 960
AVVGPSHEVQ EQSSGPFKKQ SATNLESEED SEAPVDSTLN NNRNQEFVSS SRSISGENAT 1020
SESEFTLGGD DSGVSMNPAR SALALLAMAQ SGDAVSVKIE EENQDLMHFN LQKKRAKGKG 1080
QVKEEDNSNQ KQLKRPAQGK RQNPRGTDIY LPYTPPSSES CHDGYQHQEK MRQKIKEVEE 1140
KQPEVKTGFI ASFLDFLKSG PKQQFSTLAV RMPNRTRRPG TQMVRTFCPP PLPKPSSTTP 1200
TPLVSETGGN SPSDKVDNEL KNLEHLSSFS SDEDDPGYSQ DAYKSVSTPL TTLDATSDKK 1260
KKTEALQVAT TSPTANTTGT ATTSSTTVGA VKQEPLHSTS YAVNILENIS SSESSKPIEL 1320
DGLPSDQFAK GQDTVAIEGF TDEEDTESGG EGQYRERDEF VVKIEDIETF KEALKTGKEP 1380
PAIWKVQKAL LQKFVPEIRD GQREFAATNS YLGYFGDAKS KYKRIYVKFI ENANKKEYVR 1440
VCSKKPRNKP SQTIRTVQAK PSSSSKTSDP LASKTTTTKA PSVKPKVKQP KVKAEPPPKK 1500
RKKWKEEFSS SQSDSSPEIH TSSSDDEEFE PPAPFVTRFL NTRAMKETFK SYMELLVSIA 1560
LDPDTMQALE KSNDELLLPH MKKIDGMLND NRKRLLLNLH LDQSFKNALE SFPELTIITR 1620
DSKAKSGGTA ISKIKMNGKA YNKKTLRTSK TTTKSAQEFA VDPEKIQLYS LYHSLHHYKY 1680
HVYLICKDEI SSVQKKNEDL GQEEIVQLCM KNVKWVEDLF EKFGELLNHV QQKCS 1735 
Gene Ontology
  
Interpro
 IPR025451; DUF4211. 
Pfam
 PF13926; DUF4211 
SMART
  
PROSITE
  
PRINTS