UniProt Accession

 IPYR2_MOUSE; Q91VM9; Q3UPK3; Q8BTG5; Q9D1E3 

Genbank Protein ID

 AK003660; AK090384; AK143475; BC011417 

Genbank Nucleotide ID

 BAB22922.1; BAC41194.1; BAE25392.1; AAH11417.1 

Protein Name

 Inorganic pyrophosphatase 2, mitochondrial 

Protein Synonyms/Alias

 Pyrophosphate phospho-hydrolase 2; PPase 2 

Gene Name

 Ppa2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
68	IPLKADCKEEHDIPR	acetylation	[1]
152	EDPHLRDKSTDCCGD	acetylation	[1]
171	DVCEIGSKVLSRGDV	acetylation	[1]
211	VNDPEAEKFHDIDDV	acetylation	[1]
219	FHDIDDVKKFKPGYL	acetylation	[1]
220	HDIDDVKKFKPGYLE	acetylation	[1]
237	LNWFRLYKVPDGKPE	acetylation	[1]
242	LYKVPDGKPENKFAF	acetylation	[1]
316	VPTPSMNKESNVEEE	acetylation	[2, 3]
316	VPTPSMNKESNVEEE	succinylation	[3]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

 METAL 159 159 Magnesium 1 (By similarity).
 METAL 164 164 Magnesium 1 (By similarity).
 METAL 164 164 Magnesium 2 (By similarity).
 METAL 196 196 Magnesium 1 (By similarity).
 MOD_RES 256 256 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Hydrolase; Magnesium; Metal-binding; Mitochondrion; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 330 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004427; F:inorganic diphosphatase activity; IEA:EC.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004722; F:protein serine/threonine phosphatase activity; IDA:MGI. 

Interpro

 IPR008162; Pyrophosphatase. 

Pfam

 PF00719; Pyrophosphatase 

SMART

  

PROSITE

 PS00387; PPASE 

PRINTS