CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011342
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Echinoderm microtubule-associated protein-like 1 
Protein Synonyms/Alias
 EMAP-1 
Gene Name
 Eml1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
512GNYQKLHKAEIPEQFubiquitination[1]
529IRTVAEGKGNVILIGubiquitination[1]
768VCRAHERKLLCTGDDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity). 
Sequence Annotation
 REPEAT 268 317 WD 1.
 REPEAT 322 365 WD 2.
 REPEAT 368 407 WD 3.
 REPEAT 415 453 WD 4.
 REPEAT 457 496 WD 5.
 REPEAT 540 579 WD 6.
 REPEAT 581 620 WD 7.
 REPEAT 623 662 WD 8.
 REPEAT 669 708 WD 9.
 REPEAT 736 775 WD 10.
 REPEAT 781 814 WD 11.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 814 AA 
Protein Sequence
MEDGFSSYSS LYDTSSLLQF CNDDSASAAS SMEVSDRIAS LEQRVQMQED DIQLLKSALA 60
DVVRRLNITE EQQAVLNRKG PTKARPLGQT LPLRTTVNNG TVLPKKPSAS LPAPSGARKE 120
VVVPVTKSIN RTSSSERVSP GGRRESSGDS KGSRNRTGST SSSSSGKKNS ESKPKEPAFS 180
PALQSPKPQG KRRVTHCKEE GYVKMFLRGR PVTMYMPKDQ VDSYSLEAKA ELPTKRLKLE 240
WVYGYRGRDC RNNLYLLPTG ETVYFIASVV VLYNVEEQLQ RHYAGHNDDV KCLAVHPDRI 300
TIATGQVAGT SKDGKQLPPH VRIWDSVTLN TLHVIGIGFF DRAVTCIAFS KSNGGGHLCA 360
VDDSNDHVLS VWDWQKEERL ADVKCSNEAV FAADFHPTDT NIIVTCGKSH LYFWTLEGNS 420
LNKKQGLFEK QEKPKFVLCV TFSENGDTIT GDSSGNILVW GKGTNRISYA VQGAHEGGIF 480
ALCMLRDGTL VSGGGKDRRL ISWNGNYQKL HKAEIPEQFG PIRTVAEGKG NVILIGTTRN 540
FVLQGTLSGD FTPITQGHTD ELWGLAIHAS KPQFLTCGHD KHATLWDAVG HRPVWDKIIE 600
DPAQSSGFHP SGSVVAVGTL TGRWFVFDTE TKDLVTVHTD GNEQLSVMRY SPDGNFLAIG 660
SHDNCIYIYG VTDNGRKYTR VGKCSGHSSF ITHLDWSVNS QFLVSNSGDY EILYWVPSAC 720
KQVVSVETTR DIEWATYTCT LGFHVFGVWP EGSDGTDINA VCRAHERKLL CTGDDFGKVH 780
LFSYPCSQFR APSHIYSGHS SHVTNVDFLC EDSHLISTGG KDTSIMQWRV I 831 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW. 
Interpro
 IPR005108; HELP.
 IPR011047; Quinonprotein_ADH-like_supfam.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF03451; HELP
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS