CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023316
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone deacetylase 5 
Protein Synonyms/Alias
 HD5; Antigen NY-CO-9 
Gene Name
 HDAC5 
Gene Synonyms/Alias
 KIAA0600 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
533QQQLQLGKILTKTGEacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. 
Sequence Annotation
 REGION 684 1028 Histone deacetylase.
 MOTIF 1081 1122 Nuclear export signal.
 ACT_SITE 833 833 By similarity.
 METAL 696 696 Zinc (By similarity).
 METAL 698 698 Zinc (By similarity).
 METAL 704 704 Zinc (By similarity).
 METAL 781 781 Zinc (By similarity).
 MOD_RES 259 259 Phosphoserine; by AMPK, CaMK1, SIK1 and
 MOD_RES 292 292 Phosphothreonine; by PKC.
 MOD_RES 498 498 Phosphoserine; by AMPK, CaMK1, SIK1 and
 MOD_RES 533 533 N6-acetyllysine.
 MOD_RES 661 661 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Chromatin regulator; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1122 AA 
Protein Sequence
MNSPNESDGM SGREPSLEIL PRTSLHSIPV TVEVKPVLPR AMPSSMGGGG GGSPSPVELR 60
GALVGSVDPT LREQQLQQEL LALKQQQQLQ KQLLFAEFQK QHDHLTRQHE VQLQKHLKQQ 120
QEMLAAKQQQ EMLAAKRQQE LEQQRQREQQ RQEELEKQRL EQQLLILRNK EKSKESAIAS 180
TEVKLRLQEF LLSKSKEPTP GGLNHSLPQH PKCWGAHHAS LDQSSPPQSG PPGTPPSYKL 240
PLPGPYDSRD DFPLRKTASE PNLKVRSRLK QKVAERRSSP LLRRKDGTVI STFKKRAVEI 300
TGAGPGASSV CNSAPGSGPS SPNSSHSTIA ENGFTGSVPN IPTEMLPQHR ALPLDSSPNQ 360
FSLYTSPSLP NISLGLQATV TVTNSHLTAS PKLSTQQEAE RQALQSLRQG GTLTGKFMST 420
SSIPGCLLGV ALEGDGSPHG HASLLQHVLL LEQARQQSTL IAVPLHGQSP LVTGERVATS 480
MRTVGKLPRH RPLSRTQSSP LPQSPQALQQ LVMQQQHQQF LEKQKQQQLQ LGKILTKTGE 540
LPRQPTTHPE ETEEELTEQQ EVLLGEGALT MPREGSTESE STQEDLEEED EEDDGEEEED 600
CIQVKDEEGE SGAEEGPDLE EPGAGYKKLF SDAQPLQPLQ VYQAPLSLAT VPHQALGRTQ 660
SSPAAPGGMK SPPDQPVKHL FTTGVVYDTF MLKHQCMCGN THVHPEHAGR IQSIWSRLQE 720
TGLLSKCERI RGRKATLDEI QTVHSEYHTL LYGTSPLNRQ KLDSKKLLGP ISQKMYAVLP 780
CGGIGVDSDT VWNEMHSSSA VRMAVGCLLE LAFKVAAGEL KNGFAIIRPP GHHAEESTAM 840
GFCFFNSVAI TAKLLQQKLN VGKVLIVDWD IHHGNGTQQA FYNDPSVLYI SLHRYDNGNF 900
FPGSGAPEEV GGGPGVGYNV NVAWTGGVDP PIGDVEYLTA FRTVVMPIAH EFSPDVVLVS 960
AGFDAVEGHL SPLGGYSVTA RCFGHLTRQL MTLAGGRVVL ALEGGHDLTA ICDASEACVS 1020
ALLSVELQPL DEAVLQQKPN INAVATLEKV IEIQSKHWSC VQKFAAGLGR SLREAQAGET 1080
EEAETVSAMA LLSVGAEQAQ AAAAREHSPR PAEEPMEQEP AL 1122 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.
 GO:0016604; C:nuclear body; IEA:Compara.
 GO:0004407; F:histone deacetylase activity; IDA:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.
 GO:0097372; F:NAD-dependent histone deacetylase activity (H3-K18 specific); IEA:EC.
 GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.
 GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0030183; P:B cell differentiation; TAS:UniProtKB.
 GO:0032869; P:cellular response to insulin stimulus; NAS:BHF-UCL.
 GO:0006338; P:chromatin remodeling; TAS:ProtInc.
 GO:0006342; P:chromatin silencing; TAS:ProtInc.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0070932; P:histone H3 deacetylation; IEA:GOC.
 GO:0070933; P:histone H4 deacetylation; IEA:GOC.
 GO:0006954; P:inflammatory response; TAS:UniProtKB.
 GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IMP:BHF-UCL.
 GO:0010832; P:negative regulation of myotube differentiation; IMP:BHF-UCL.
 GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0007219; P:Notch signaling pathway; TAS:Reactome.
 GO:0002076; P:osteoblast development; IEA:Compara.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0043393; P:regulation of protein binding; IMP:BHF-UCL.
 GO:0042220; P:response to cocaine; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000286; His_deacetylse.
 IPR023801; His_deacetylse_dom.
 IPR024643; Hist_deacetylase_Gln_rich_N.
 IPR017320; Histone_deAcase_II_euk. 
Pfam
 PF12203; HDAC4_Gln
 PF00850; Hist_deacetyl 
SMART
  
PROSITE
  
PRINTS
 PR01270; HDASUPER.