CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039902
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Hairy/enhancer-of-split-related with YRPW motif-like protein 
Protein Synonyms/Alias
  
Gene Name
 HEYL 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
48LVPTAFEKQGSSKLEubiquitination[1, 2, 3]
56QGSSKLEKAEVLQMTubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 300 AA 
Protein Sequence
MARPLSTPSS SQMQARKKHR GIIEKRRRDR INSSLSELRR LVPTAFEKQG SSKLEKAEVL 60
QMTVDHLKML HATGGTGFFD ARALAVDFRS IGFRECLTEV IRYLGVLEGP SSRADPVRIR 120
LLSHLNSYAA EMEPSPTPTG PLAFPAWPWS FFHSCPGLPA LSNQLAILGR VPSPVLPGVS 180
SPAYPIPALR TAPLRRATGI ILPARRNVLP SRGASSTRRA RPLERPATPV PVAPSSRAAR 240
SSHIAPLLQS SSPTPPGPTG SAAYVAVPTP NSSSPGPAGR PAGAMLYHSW VSEITEIGAF 300 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Compara.
 GO:0000983; F:RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0001106; F:RNA polymerase II transcription corepressor activity; IEA:Compara.
 GO:0003181; P:atrioventricular valve morphogenesis; IEA:Compara.
 GO:0003208; P:cardiac ventricle morphogenesis; IEA:Compara.
 GO:0071773; P:cellular response to BMP stimulus; IEA:Compara.
 GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Compara.
 GO:0032835; P:glomerulus development; IEA:Compara.
 GO:0003151; P:outflow tract morphogenesis; IEA:Compara.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0072014; P:proximal tubule development; IEA:Compara.
 GO:0003184; P:pulmonary valve morphogenesis; IEA:Compara.
 GO:0060412; P:ventricular septum morphogenesis; IEA:Compara. 
Interpro
 IPR011598; bHLH_dom.
 IPR003650; Orange.
 IPR018352; Orange_subgr. 
Pfam
 PF07527; Hairy_orange
 PF00010; HLH 
SMART
 SM00353; HLH
 SM00511; ORANGE 
PROSITE
 PS50888; BHLH
 PS51054; ORANGE 
PRINTS