| Tag | Content |
|---|
| CPLM ID | CPLM-019822 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tyrosine-protein phosphatase non-receptor type 18 |
Protein Synonyms/Alias | Brain-derived phosphatase |
Gene Name | PTPN18 |
Gene Synonyms/Alias | BDP1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 32 | VLAGEFSKRCERYWA | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. |
Sequence Annotation | DOMAIN 26 291 Tyrosine-protein phosphatase.
REGION 229 235 Substrate binding (By similarity).
ACT_SITE 229 229 Phosphocysteine intermediate (By
BINDING 197 197 Substrate (By similarity).
BINDING 276 276 Substrate (By similarity).
MOD_RES 389 389 Phosphotyrosine (By similarity).
MOD_RES 426 426 Phosphotyrosine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 460 AA |
Protein Sequence | MSRSLDSARS FLERLEARGG REGAVLAGEF SKRCERYWAQ EQEPLQTGLF CITLIKEKWL 60
NEDIMLRTLK VTFQKESRSV YQLQYMSWPD RGVPSSPDHM LAMVEEARRL QGSGPEPLCV 120
HCSAGCGRTG VLCTVDYVRQ LLLTQMIPPD FSLFDVVLKM RKQRPAAVQT EEQYRFLYHT 180
VAQMFCSTLQ NASPHYQNIK ENCAPLYDDA LFLRTPQALL AIPRPPGGVL RSISVPGSPG 240
HAMADTYAVV QKRGAPAGAG SGTQTGTGTG TGARSAEEAP LYSKVTPRAQ RPGAHAEDAR 300
GTLPGRVPAD QSPAGSGAYE DVAGGAQTGG LGFNLRIGRP KGPRDPPAEW TRV 353 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |