| Tag | Content |
|---|
| CPLM ID | CPLM-011652 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | PHO85 cyclin-8 |
Protein Synonyms/Alias | |
Gene Name | PCL8 |
Gene Synonyms/Alias | YPL219W; P1745 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 321 | SDDEALSKFRENIEL | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL10, negatively controls glycogen accumulation under favorable growth conditions. Involved in phosphorylation and negative regulation of glycogen synthase GSY2. Also has minor GLC8 kinase activity. |
Sequence Annotation | MOD_RES 32 32 Phosphoserine. |
Keyword | Carbohydrate metabolism; Complete proteome; Cyclin; Cytoplasm; Glycogen metabolism; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 492 AA |
Protein Sequence | MANDQDPNKS LINDALTRSM SEFYDDDDDN DSDMCRANDE GEDVFDLPLK VGVSQSRNFS 60
EVNDVLDPLS SLHGPSKKVR FEQQKQQQQH QQLHNDFNTD FNLKSPSSKK MGVEQLIQSA 120
NEINDYLANN IDKVNSFNSE LLSGSGKLPG RVKSDTATQG TGRLDSMSNF ALSDTELDND 180
DDNYLLDPLA NASSTTPTVE HHGYSLLDKA LSTSDKEKIY TNKVNSNSQI DTDNHSHESG 240
NTTNNETDEN ESSEILDYTK FDSFPYPPSS APNGEPPDLK VLSIECEQEN EKELRRISLL 300
LDHYESIPKI PELSDDEALS KFRENIELIL QLSKKINDNA NTLAISSEDP QKFVNFVMKN 360
PPSLSFRDFI DRIQNKCMFG AVVYLGATYL LQLVFLTRDE MDGPIKLKAK LQEDQAHRII 420
ISTIRIATKL LEDFVHSQNY ICKVFGISKR LLTKLEISFM ASVNFDGLMI TCEKLEKTLH 480
ILDDTRQALG NT 492 |
Gene Ontology | GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; TAS:SGD. GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; ISS:SGD. GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW. GO:0045719; P:negative regulation of glycogen biosynthetic process; IMP:SGD. GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |