CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019981
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sorting nexin-1 
Protein Synonyms/Alias
  
Gene Name
 Snx1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
237SSAEFLEKRRAALERacetylation[1]
442ARLLWANKPDKLQQAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). 
Sequence Annotation
 DOMAIN 143 272 PX.
 DOMAIN 302 522 BAR.
 BINDING 186 186 Phosphatidylinositol 3-phosphate (By
 BINDING 188 188 Phosphatidylinositol 3-phosphate; via
 BINDING 214 214 Phosphatidylinositol 3-phosphate (By
 BINDING 238 238 Phosphatidylinositol 3-phosphate (By
 MOD_RES 32 32 Phosphoserine (By similarity).
 MOD_RES 39 39 Phosphoserine (By similarity).
 MOD_RES 188 188 Phosphoserine (By similarity).
 MOD_RES 237 237 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Endosome; Golgi apparatus; Lipid-binding; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 522 AA 
Protein Sequence
MASGGGGCSA SERLPPPFPG MDPESEGAAG GSEPEAGDSD TEGEDIFTGA AAASKPQSPK 60
KTTSLFPIKN GSKENGIHEE QDQEPQDLFA DATVELSLDS TQNNQKTMPG KTLIPHPTQE 120
ATNSPKPQPS YEELEEEEQE DQFDLTVGIT DPEKIGDGMN AYVAYKVTTQ TSLPMFRSRQ 180
FAVKRRFSDF LGLYEKLSEK HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA 240
ALERYLQRIV NHPTMLQDPD VREFLEKEEL PRAVGTQALS GAGLLKMFNK ATDAVSKMTI 300
KMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTALFAKS LAMLGSSEDN 360
TALSRALSQL AEVEEKIEQL HQEQANNDFF LLAELLSDYI RLLAIVRAAF DQRMKTWQRW 420
QDAQATLQKK RESEARLLWA NKPDKLQQAK DEITEWESRV TQYERDFERI STVVRKEVTR 480
FEKEKSKDFK NHVIKYLETL LHSQQQLAKY WEAFLPEARA IS 522 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0010008; C:endosome membrane; ISS:UniProtKB.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0034498; P:early endosome to Golgi transport; IEA:Compara.
 GO:0016197; P:endosomal transport; IEP:RGD.
 GO:0006886; P:intracellular protein transport; IEA:Compara.
 GO:0045732; P:positive regulation of protein catabolic process; IMP:RGD. 
Interpro
 IPR001683; Phox.
 IPR005329; Sorting_nexin_N.
 IPR015404; Vps5_C. 
Pfam
 PF00787; PX
 PF03700; Sorting_nexin
 PF09325; Vps5 
SMART
 SM00312; PX 
PROSITE
 PS51021; BAR
 PS50195; PX 
PRINTS