CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005197
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 High-affinity glucose transporter HXT2 
Protein Synonyms/Alias
  
Gene Name
 HXT2 
Gene Synonyms/Alias
 YMR011W; YM8270.15 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
26HSTPIVQKLETDESPubiquitination[1]
94KRRFGQMKSDGTYYLubiquitination[1]
309WGELFSNKGAILPRVubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 High-affinity glucose transporter. Is only indispensable for growth on low glucose-containing media, because S.cerevisiae possesses other sugar transporters. 
Sequence Annotation
 MOD_RES 11 11 Phosphoserine.
 MOD_RES 13 13 Phosphoserine.
 MOD_RES 17 17 Phosphoserine.
 MOD_RES 20 20 Phosphoserine.
 MOD_RES 29 29 Phosphothreonine.
 MOD_RES 32 32 Phosphoserine.
 MOD_RES 266 266 Phosphoserine; by PKA (Potential).
 MOD_RES 539 539 Phosphoserine; by PKA (Potential).
 CARBOHYD 82 82 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat; Sugar transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 541 AA 
Protein Sequence
MSEFATSRVE SGSQQTSIHS TPIVQKLETD ESPIQTKSEY TNAELPAKPI AAYWTVICLC 60
LMIAFGGFVF GWDTGTISGF VNQTDFKRRF GQMKSDGTYY LSDVRTGLIV GIFNIGCAFG 120
GLTLGRLGDM YGRRIGLMCV VLVYIVGIVI QIASSDKWYQ YFIGRIISGM GVGGIAVLSP 180
TLISETAPKH IRGTCVSFYQ LMITLGIFLG YCTNYGTKDY SNSVQWRVPL GLNFAFAIFM 240
IAGMLMVPES PRFLVEKGRY EDAKRSLAKS NKVTIEDPSI VAEMDTIMAN VETERLAGNA 300
SWGELFSNKG AILPRVIMGI MIQSLQQLTG NNYFFYYGTT IFNAVGMKDS FQTSIVLGIV 360
NFASTFVALY TVDKFGRRKC LLGGSASMAI CFVIFSTVGV TSLYPNGKDQ PSSKAAGNVM 420
IVFTCLFIFF FAISWAPIAY VIVAESYPLR VKNRAMAIAV GANWIWGFLI GFFTPFITSA 480
IGFSYGYVFM GCLVFSFFYV FFFVCETKGL TLEEVNEMYV EGVKPWKSGS WISKEKRVSE 540
E 541 
Gene Ontology
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0005353; F:fructose transmembrane transporter activity; TAS:SGD.
 GO:0005355; F:glucose transmembrane transporter activity; IDA:SGD.
 GO:0015578; F:mannose transmembrane transporter activity; TAS:SGD.
 GO:0015146; F:pentose transmembrane transporter activity; IMP:SGD. 
Interpro
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR005828; Sub_transporter.
 IPR003663; Sugar/inositol_transpt.
 IPR005829; Sugar_transporter_CS. 
Pfam
 PF00083; Sugar_tr 
SMART
  
PROSITE
 PS50850; MFS
 PS00216; SUGAR_TRANSPORT_1
 PS00217; SUGAR_TRANSPORT_2 
PRINTS
 PR00171; SUGRTRNSPORT.