UniProt Accession

 GBRB2_HUMAN; P47870; A8K115; A8K1A0; D1LYT0; D1LYT1; Q16323; Q4FZB2 

Genbank Protein ID

 S67368; S77554; S77553; GU086163; GU086164; AK289730; AK289815; CH471062; BC099705; BC099719; BC105639 

Genbank Nucleotide ID

 AAB29370.1; AAB33983.1; AAB33982.1; ACY69094.1; ACY69095.1; BAF82419.1; BAF82504.1; EAW61543.1; AAH99705.1; AAH99719.1; AAI05640.1 

Protein Name

 Gamma-aminobutyric acid receptor subunit beta-2 

Protein Synonyms/Alias

 GABA(A) receptor subunit beta-2 

Gene Name

 GABRB2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
45	ETVDRLLKGYDIRLR	ubiquitination	[1, 2]

Reference

 [1] Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry.
 Denis NJ, Vasilescu J, Lambert JP, Smith JC, Figeys D.
 Proteomics. 2007 Mar;7(6):868-74. [PMID: 17370265]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 

Sequence Annotation

 MOD_RES 434 434 Phosphotyrosine (By similarity).
 MOD_RES 441 441 Phosphotyrosine (By similarity).
 CARBOHYD 32 32 N-linked (GlcNAc...) (Potential).
 CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
 CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
 DISULFID 160 174 By similarity.
 CROSSLNK 45 45 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Alternative splicing; Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Isopeptide bond; Ligand-gated ion channel; Membrane; Phosphoprotein; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 512 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
 GO:0004890; F:GABA-A receptor activity; ISS:BHF-UCL.
 GO:0005237; F:inhibitory extracellular ligand-gated ion channel activity; IEA:Compara.
 GO:0090102; P:cochlea development; IEA:Compara.
 GO:0007214; P:gamma-aminobutyric acid signaling pathway; TAS:ProtInc.
 GO:0060119; P:inner ear receptor cell development; IEA:Compara.
 GO:0060384; P:innervation; IEA:Compara.
 GO:0034220; P:ion transmembrane transport; TAS:Reactome.
 GO:0007605; P:sensory perception of sound; IEA:Compara.
 GO:0051932; P:synaptic transmission, GABAergic; ISS:BHF-UCL. 

Interpro

 IPR006028; GABAA_rcpt.
 IPR002289; GABAAb_rcpt.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS. 

Pfam

 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 

SMART

  

PROSITE

 PS00236; NEUROTR_ION_CHANNEL 

PRINTS

 PR01160; GABAARBETA.
 PR00253; GABAARECEPTR.
 PR00252; NRIONCHANNEL.