UniProt Accession

 ADK_RAT; Q64640; O09162; Q642G1 

Genbank Protein ID

 U90340; BC081712; U57042 

Genbank Nucleotide ID

 AAB50236.1; AAH81712.1; AAB03110.1 

Protein Name

 Adenosine kinase 

Protein Synonyms/Alias

 AK; Adenosine 5'-phosphotransferase 

Gene Name

 Adk 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
8	MAAADEPKPKKLKVE	acetylation	[1]
10	AADEPKPKKLKVEAP	acetylation	[1]
46	VDKDFLDKYSLKPND	acetylation	[1]
50	FLDKYSLKPNDQILA	acetylation	[1]
70	ELFDELVKKFKVEYH	acetylation	[1]
73	DELVKKFKVEYHAGG	acetylation	[1]
255	REQGFETKDIKEIAR	acetylation	[1]
258	GFETKDIKEIARKTQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. 

Sequence Annotation

 ACT_SITE 316 316 By similarity.
 METAL 48 48 Magnesium 1 (By similarity).
 METAL 147 147 Magnesium 2 (By similarity).
 MOD_RES 76 76 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Purine salvage; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 361 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0004001; F:adenosine kinase activity; IDA:RGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0046085; P:adenosine metabolic process; IDA:RGD.
 GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
 GO:0032922; P:circadian regulation of gene expression; IEP:RGD.
 GO:0006175; P:dATP biosynthetic process; IEA:Compara.
 GO:0010613; P:positive regulation of cardiac muscle hypertrophy; IMP:RGD.
 GO:0042102; P:positive regulation of T cell proliferation; IEP:RGD.
 GO:0006166; P:purine ribonucleoside salvage; NAS:RGD.
 GO:0044342; P:type B pancreatic cell proliferation; IMP:RGD. 

Interpro

 IPR001805; Adenokinase.
 IPR002173; Carboh/pur_kinase_PfkB_CS.
 IPR011611; PfkB_dom. 

Pfam

 PF00294; PfkB 

SMART

  

PROSITE

 PS00583; PFKB_KINASES_1
 PS00584; PFKB_KINASES_2 

PRINTS

 PR00989; ADENOKINASE.