CPLM-000922

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-000922

UniProt Accession

KIF1B_HUMAN; O60333; A6NFS8; A6NKQ4; Q4VXC3; Q4VXC4; Q4VXC5; Q4VXC6; Q96Q94; Q9BV80; Q9P280

Genbank Protein ID

AX039604; AB017133; AF257176; AY043362; AB088210; AY139835; AB011163; AB040881; AL139424; AL358013; AL139424; AL358013; AL358013; AL139424; AL358013; AL139424; AL358013; AL139424; AL358013; AL139424; AL358013; BC001415; BC115395; BT007174; AK022977

Genbank Nucleotide ID

CAC16629.1; BAB69038.1; AAK49332.1; AAK85155.1; BAE02543.1; AAN17742.1; BAA25517.2; BAA95972.2; CAI95752.1; CAI95752.1; CAI95753.1; CAI95753.1; CAI95219.1; CAI95219.1; CAI95220.1; CAI95220.1; CAI95221.1; CAI95221.1; CAI95222.1; CAI95754.1; CAI95754.1; AAH01415.1; AAI15396.1; AAP35838.1; BAB14341.1

Protein Name

Kinesin-like protein KIF1B

Protein Synonyms/Alias

Klp

Gene Name

KIF1B

Gene Synonyms/Alias

KIAA0591; KIAA1448

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
784	NAISVELKKKVQFQF	ubiquitination	[1]

Reference

[1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]

Functional Description

Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis.

Sequence Annotation

DOMAIN 1 361 Kinesin-motor.
DOMAIN 556 612 FHA.
DOMAIN 1702 1799 PH.
NP_BIND 97 104 ATP (By similarity).
REGION 270 350 Interaction with KBP.
MOD_RES 1057 1057 Phosphoserine.
MOD_RES 1075 1075 Phosphothreonine.
MOD_RES 1454 1454 Phosphoserine.
MOD_RES 1487 1487 Phosphoserine.
MOD_RES 1610 1610 Phosphoserine.
MOD_RES 1613 1613 Phosphoserine.

Keyword

3D-structure; Alternative splicing; Apoptosis; ATP-binding; Charcot-Marie-Tooth disease; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Disease mutation; Microtubule; Mitochondrion; Motor protein; Neuropathy; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1816 AA

Protein Sequence

MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT 60
SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP 120
QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 180
LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK 240
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDN CTSKSKKKKK 300
TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIKCNAVI 360
NEDPNAKLVR ELKEEVTRLK DLLRAQGLGD IIDIDPLIDD YSGSGSKYLK DFQNNKHRYL 420
LASENQRPGH FSTASMGSLT SSPSSCSLSS QVGLTSVTSI QERIMSTPGG EEAIERLKES 480
EKIIAELNET WEEKLRKTEA IRMEREALLA EMGVAIREDG GTLGVFSPKK TPHLVNLNED 540
PLMSECLLYY IKDGITRVGQ ADAERRQDIV LSGAHIKEEH CIFRSERSNS GEVIVTLEPC 600
ERSETYVNGK RVSQPVQLRS GNRIIMGKNH VFRFNHPEQA RAEREKTPSA ETPSEPVDWT 660
FAQRELLEKQ GIDMKQEMEK RLQEMEILYK KEKEEADLLL EQQRLDYESK LQALQKQVET 720
RSLAAETTEE EEEEEEVPWT QHEFELAQWA FRKWKSHQFT SLRDLLWGNA VYLKEANAIS 780
VELKKKVQFQ FVLLTDTLYS PLPPELLPTE MEKTHEDRPF PRTVVAVEVQ DLKNGATHYW 840
SLEKLKQRLD LMREMYDRAG EMASSAQDES ETTVTGSDPF YDRFHWFKLV GSSPIFHGCV 900
NERLADRTPS PTFSTADSDI TELADEQQDE MEDFDDEAFV DDAGSDAGTE EGSDLFSDGH 960
DPFYDRSPWF ILVGRAFVYL SNLLYPVPLI HRVAIVSEKG EVRGFLRVAV QAIAADEEAP 1020
DYGSGIRQSG TAKISFDNEY FNQSDFSSVA MTRSGLSLEE LRIVEGQGQS SEVITPPEEI 1080
SRINDLDLKS STLLDGKMVM EGFSEEIGNH LKLGSAFTFR VTVLQASGIL PEYADIFCQF 1140
NFLHRHDEAF STEPLKNNGR GSPLAFYHVQ NIAVEITESF VDYIKTKPIV FEVFGHYQQH 1200
PLHLQGQELN SPPQPCRRFF PPPMPLSKPV PATKLNTMSK TSLGQSMSKY DLLVWFEISE 1260
LEPTGEYIPA VVDHTAGLPC QGTFLLHQGI QRRITVTIIH EKGSELHWKD VRELVVGRIR 1320
NKPEVDEAAV DAILSLNIIS AKYLKSSHNS SRTFYRFEAV WDSSLHNSLL LNRVTPYGEK 1380
IYMTLSAYLE LDHCIQPAVI TKDVCMVFYS RDAKISPPRS LRSLFGSGYS KSPDSNRVTG 1440
IYELSLCKMS DTGSPGMQRR RRKILDTSVA YVRGEENLAG WRPRGDSLIL EHQWELEKLE 1500
LLHEVEKTRH FLLLRERLGD SIPKSLSDSL SPSLSSGTLS TSTSISSQIS TTTFESAITP 1560
SESSGYDSGD IESLVDREKE LATKCLQLLT HTFNREFSQV HGSVSDCKLS DISPIGRDPS 1620
ESSFSSATLT PSSTCPSLVD SRSNSLDQKT PEANSRASSP CPEFEQFQIV PAVETPYLAR 1680
AGKNEFLNLV PDIEEIRPSS VVSKKGYLHF KEPLYSNWAK HFVVVRRPYV FIYNSDKDPV 1740
ERGIINLSTA QVEYSEDQQA MVKTPNTFAV CTKHRGVLLQ ALNDKDMNDW LYAFNPLLAG 1800
TIRPGHLASE IIREDKSVSF SCQ 1823

Gene Ontology

GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0005875; C:microtubule associated complex; ISS:UniProtKB.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0043005; C:neuron projection; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0016887; F:ATPase activity; ISS:UniProtKB.
GO:0019894; F:kinesin binding; TAS:UniProtKB.
GO:0003777; F:microtubule motor activity; ISS:UniProtKB.
GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0008089; P:anterograde axon cargo transport; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Compara.
GO:0007274; P:neuromuscular synaptic transmission; ISS:UniProtKB.
GO:0007270; P:neuron-neuron synaptic transmission; ISS:UniProtKB.

Interpro

IPR000253; FHA_dom.
IPR022140; KIF1B.
IPR022164; Kinesin-like.
IPR019821; Kinesin_motor_CS.
IPR001752; Kinesin_motor_dom.
IPR027417; P-loop_NTPase.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR008984; SMAD_FHA_domain.

Pfam

PF12473; DUF3694
PF00498; FHA
PF12423; KIF1B
PF00225; Kinesin
PF00169; PH

SMART

SM00240; FHA
SM00129; KISc
SM00233; PH

PROSITE

PS50006; FHA_DOMAIN
PS00411; KINESIN_MOTOR_DOMAIN1
PS50067; KINESIN_MOTOR_DOMAIN2
PS50003; PH_DOMAIN

PRINTS

PR00380; KINESINHEAVY.