CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005223
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Endothelial transcription factor GATA-2 
Protein Synonyms/Alias
 GATA-binding protein 2 
Gene Name
 GATA2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
102LPWLDGGKAALSAAAacetylation[1]
222VSLTESMKMESGSPLsumoylation[2]
281PASSFTPKQRSKARSacetylation[1]
285FTPKQRSKARSCSEGacetylation[1]
334GQNRPLIKPKRRLSAacetylation[1]
336NRPLIKPKRRLSAARacetylation[1]
389VNRPLTMKKEGIQTRacetylation[1]
389VNRPLTMKKEGIQTRsumoylation[2]
390NRPLTMKKEGIQTRNacetylation[1]
399GIQTRNRKMSNKSKKacetylation[1]
403RNRKMSNKSKKSKKGacetylation[1]
405RKMSNKSKKSKKGAEacetylation[1]
406KMSNKSKKSKKGAECacetylation[1]
408SNKSKKSKKGAECFEacetylation[1]
409NKSKKSKKGAECFEEacetylation[1]
Reference
 [1] Functional regulation of GATA-2 by acetylation.
 Hayakawa F, Towatari M, Ozawa Y, Tomita A, Privalsky ML, Saito H.
 J Leukoc Biol. 2004 Mar;75(3):529-40. [PMID: 15001660]
 [2] Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy.
 Chun TH, Itoh H, Subramanian L, Iñiguez-Lluhí JA, Nakao K.
 Circ Res. 2003 Jun 13;92(11):1201-8. [PMID: 12750312] 
Functional Description
 Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. 
Sequence Annotation
 ZN_FING 295 319 GATA-type 1.
 ZN_FING 349 373 GATA-type 2.  
Keyword
 Activator; Alternative splicing; Complete proteome; Disease mutation; DNA-binding; Metal-binding; Nucleus; Phagocytosis; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 480 AA 
Protein Sequence
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY 60
ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHNPWTVSP 120
FSKTPLHPSA AGGPGGPLSV YPGAGGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE 180
VSPDPSTTGA ASPASSSAGG SAARGEDKDG VKYQVSLTES MKMESGSPLR PGLATMGTQP 240
ATHHPIPTYP SYVPAAAHDY SSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA 300
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW 360
RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SNKSKKSKKG AECFEELSKC 420
MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG 480 
Gene Ontology
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0001158; F:enhancer sequence-specific DNA binding; IDA:MGI.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0021533; P:cell differentiation in hindbrain; IEA:Compara.
 GO:0001709; P:cell fate determination; IEA:Compara.
 GO:0048469; P:cell maturation; IEA:Compara.
 GO:0021954; P:central nervous system neuron development; IEA:Compara.
 GO:0060216; P:definitive hemopoiesis; IEA:Compara.
 GO:0001892; P:embryonic placenta development; IEA:Compara.
 GO:0035854; P:eosinophil fate commitment; IDA:BHF-UCL.
 GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Compara.
 GO:0042472; P:inner ear morphogenesis; IEA:Compara.
 GO:0045599; P:negative regulation of fat cell differentiation; IMP:UniProtKB.
 GO:0070345; P:negative regulation of fat cell proliferation; IMP:UniProtKB.
 GO:0045650; P:negative regulation of macrophage differentiation; IEA:Compara.
 GO:2000178; P:negative regulation of neural precursor cell proliferation; IDA:MGI.
 GO:0045746; P:negative regulation of Notch signaling pathway; IDA:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0048663; P:neuron fate commitment; IEA:Compara.
 GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
 GO:0021983; P:pituitary gland development; IEA:Compara.
 GO:0045766; P:positive regulation of angiogenesis; IDA:MGI.
 GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Compara.
 GO:0045654; P:positive regulation of megakaryocyte differentiation; IEA:Compara.
 GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0035065; P:regulation of histone acetylation; IEA:Compara.
 GO:0060872; P:semicircular canal development; IEA:Compara.
 GO:0035019; P:somatic stem cell maintenance; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IDA:UniProtKB.
 GO:0001655; P:urogenital system development; IEA:Compara.
 GO:0021514; P:ventral spinal cord interneuron differentiation; IEA:Compara. 
Interpro
 IPR016374; TF_GATA-1/2/3.
 IPR000679; Znf_GATA.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00320; GATA 
SMART
 SM00401; ZnF_GATA 
PROSITE
 PS00344; GATA_ZN_FINGER_1
 PS50114; GATA_ZN_FINGER_2 
PRINTS
 PR00619; GATAZNFINGER.