CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001430
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein lin-7 homolog C 
Protein Synonyms/Alias
 Lin-7C; mLin7C; Mammalian lin-seven protein 3; MALS-3; Vertebrate lin-7 homolog 3; Veli-3 
Gene Name
 Lin7c 
Gene Synonyms/Alias
 Mals3; Veli3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
23RAIELLEKLQRSGEVubiquitination[1]
76VRANATAKATVAAFAubiquitination[1]
111GFNIMGGKEQNSPIYubiquitination[1]
176LVVRYTPKVLEEMESubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. 
Sequence Annotation
 DOMAIN 10 65 L27.
 DOMAIN 93 175 PDZ.
 MOTIF 2 13 Kinase interacting site (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  
Keyword
 Acetylation; Cell junction; Cell membrane; Complete proteome; Direct protein sequencing; Exocytosis; Membrane; Postsynaptic cell membrane; Protein transport; Reference proteome; Synapse; Synaptosome; Tight junction; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 197 AA 
Protein Sequence
MAALGEPVRL ERDICRAIEL LEKLQRSGEV PPQKLQALQR VLQSEFCNAV REVYEHVYET 60
VDISSSPEVR ANATAKATVA AFAASEGHSH PRVVELPKTE EGLGFNIMGG KEQNSPIYIS 120
RIIPGGIADR HGGLKRGDQL LSVNGVSVEG EHHEKAVELL KAAQGKVKLV VRYTPKVLEE 180
MESRFEKMRS AKRRQQT 197 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
 GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
 GO:0007269; P:neurotransmitter secretion; IGI:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR004172; L27.
 IPR014775; L27_C.
 IPR017365; Lin-7_homologue.
 IPR001478; PDZ. 
Pfam
 PF02828; L27
 PF00595; PDZ 
SMART
 SM00569; L27
 SM00228; PDZ 
PROSITE
 PS51022; L27
 PS50106; PDZ 
PRINTS