UniProt Accession

 PANX1_HUMAN; Q96RD7; O75968; Q543A0; Q6UW26; Q96AM9; Q96L77; Q96RS5 

Genbank Protein ID

 AF093239; AF398509; AF398508; AF398506; AF398507; AY048509; AY359023; AK074897; AP003966; BC016931; AH010945 

Genbank Nucleotide ID

 AAC61779.1; AAK91714.1; AAK91713.1; AAK91713.1; AAK91713.1; AAL06604.1; AAQ89382.1; BAC11276.1; AAH16931.1; AAK73361.1 

Protein Name

 Pannexin-1 

Protein Synonyms/Alias

  

Gene Name

 PANX1 

Gene Synonyms/Alias

 MRS1; UNQ2529/PRO6028 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
307	RQKTDVLKVYEILPT	ubiquitination	[1]
343	EENISEVKSYKCLKV	ubiquitination	[1]
355	LKVLENIKSSGQGID	ubiquitination	[2]
381	KMDVVDGKTPMSAEM	ubiquitination	[2, 3, 4]
409	MNIDSETKANNGEKN	ubiquitination	[1, 3, 5]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. 

Sequence Annotation

 MOD_RES 40 40 S-nitrosocysteine (By similarity).
 MOD_RES 347 347 S-nitrosocysteine (By similarity).
 CARBOHYD 255 255 N-linked (GlcNAc...).  

Keyword

 Alternative splicing; Calcium; Calcium channel; Calcium transport; Cell junction; Cell membrane; Complete proteome; Endoplasmic reticulum; Gap junction; Glycoprotein; Ion channel; Ion transport; Membrane; Polymorphism; Reference proteome; S-nitrosylation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 426 AA 

Protein Sequence

Gene Ontology

 GO:0032059; C:bleb; IDA:BHF-UCL.
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:BHF-UCL.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005262; F:calcium channel activity; IMP:UniProtKB.
 GO:0055077; F:gap junction hemi-channel activity; IDA:UniProtKB.
 GO:0022840; F:leak channel activity; IMP:UniProtKB.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0035872; P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; TAS:Reactome.
 GO:0050717; P:positive regulation of interleukin-1 alpha secretion; IEA:Compara.
 GO:0050718; P:positive regulation of interleukin-1 beta secretion; IDA:BHF-UCL.
 GO:0034214; P:protein hexamerization; IDA:UniProtKB.
 GO:0033198; P:response to ATP; IEA:Compara.
 GO:0002931; P:response to ischemia; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 

Interpro

 IPR000990; Innexin. 

Pfam

 PF00876; Innexin 

SMART

  

PROSITE

 PS51013; PANNEXIN 

PRINTS