| Tag | Content |
|---|
| CPLM ID | CPLM-011265 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription initiation factor TFIID subunit 7 |
Protein Synonyms/Alias | TAFII-67; TBP-associated factor 67 kDa; TBP-associated factor 7 |
Gene Name | TAF7 |
Gene Synonyms/Alias | TAF67; YMR227C; YM9959.09C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 15 | KPRGPGEKDQPLEGE | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre- initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. TAF7 is responsible for the recruitment of BDF1 to TATA element containing promoters. |
Sequence Annotation | MOD_RES 99 99 Phosphotyrosine.
MOD_RES 101 101 Phosphoserine.
MOD_RES 104 104 Phosphoserine. |
Keyword | Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 590 AA |
Protein Sequence | MAVIRIKKPR GPGEKDQPLE GEPKLKRIRI KTKVTDEDIK PKPKLKINLK KKKESADGKE 60
KKNSLKLKLN LKKNEEPVKK IHKAPKLRLK PIRIPGEAYD SEASDIEDDP LIESGVILRI 120
LPDIQLEFVK NSLESGDYSG ISIKWKNERH AVVTINDVMY GAILVDLPTV IEVNKSVDRK 180
NLLKTFDVSQ MLLCIRPIQE EEEVYALEAP DTEDLVVKHF EGIEDEIWEN KETFLKGYNG 240
APLSDMEAKH LKEIALKGYD YKHGISPPLY NVRNRRFRRK MDPNEIDYVE KVVDMLLKQD 300
KQAEEVSYDL VDKSELQARQ ERVSSWENFK EEPGEPLSRP ALKKEEIHTI ASAVGKQGAE 360
EEGEEGMEEE EEEDLDLGAA FESEEEGSGA EGDKEQQQEE VGDEVDQDTG GEDDDDDDDG 420
DIEAAGGESE SDDEKDENRQ HTELLADELN ELETTLAHTK HKLSKATNPL LKSRFIDSIK 480
KLEKEAELKR KQLQQTEDSV QKQHQHRSDA ETANNVEEEE EEEEEEEEED EVDEDEEDDE 540
ENDEDEDNVH EREHIQENKV VRELDEAPAE ETLDQNDLDM MMLFGAEGDE 590 |
Gene Ontology | GO:0005669; C:transcription factor TFIID complex; IDA:SGD. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0051123; P:RNA polymerase II transcriptional preinitiation complex assembly; IMP:SGD. |
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