UniProt Accession

 GLYA_MYCPN; P78011 

Genbank Protein ID

 U00089 

Genbank Nucleotide ID

 AAB95914.1 

Protein Name

 Serine hydroxymethyltransferase 

Protein Synonyms/Alias

 SHMT; Serine methylase 

Gene Name

 glyA 

Gene Synonyms/Alias

 MPN_576; MP266 

Created Date

 July 27, 2013 

Organism

 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 

NCBI Taxa ID

 272634 

Lysine Modification

Position	Peptide	Type	References
240	NNEAIIRKLDSGVFP	acetylation	[1]
266	AAKYVCFKEALQPKY	acetylation	[1]
272	FKEALQPKYKQYIQN	acetylation	[1]
292	ASMASWFKQQGYRVI	acetylation	[1]
393	EVKKAVLKLLERFPL	acetylation	[1]

Reference

 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 

Functional Description

 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity). 

Sequence Annotation

 REGION 115 117 Substrate binding (By similarity).
 BINDING 25 25 Pyridoxal phosphate (By similarity).
 BINDING 45 45 Pyridoxal phosphate (By similarity).
 BINDING 47 47 Substrate (By similarity).
 BINDING 54 54 Substrate (By similarity).
 BINDING 55 55 Pyridoxal phosphate (By similarity).
 BINDING 89 89 Pyridoxal phosphate (By similarity).
 BINDING 111 111 Substrate; via carbonyl oxygen (By
 BINDING 166 166 Pyridoxal phosphate (By similarity).
 BINDING 194 194 Pyridoxal phosphate (By similarity).
 BINDING 219 219 Pyridoxal phosphate (By similarity).
 BINDING 226 226 Pyridoxal phosphate (By similarity).
 BINDING 252 252 Pyridoxal phosphate; via amide nitrogen
 BINDING 348 348 Pyridoxal phosphate (By similarity).
 MOD_RES 220 220 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Amino-acid biosynthesis; Complete proteome; Cytoplasm; One-carbon metabolism; Pyridoxal phosphate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:HAMAP.
 GO:0030170; F:pyridoxal phosphate binding; IEA:HAMAP.
 GO:0019264; P:glycine biosynthetic process from serine; IEA:HAMAP.
 GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. 

Interpro

 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR001085; Ser_HO-MeTrfase.
 IPR019798; Ser_HO-MeTrfase_PLP_BS. 

Pfam

 PF00464; SHMT 

SMART

  

PROSITE

 PS00096; SHMT 

PRINTS