UniProt Accession

 ZNT1_HUMAN; Q9Y6M5; Q0VAK9; Q9BZF6 

Genbank Protein ID

 AF323590; AB451467; CH471100; BC121015; BC121016; AF048701 

Genbank Nucleotide ID

 AAG53405.1; BAG70281.1; EAW93412.1; AAI21016.1; AAI21017.1; AAD29840.1 

Protein Name

 Zinc transporter 1 

Protein Synonyms/Alias

 ZnT-1; Solute carrier family 30 member 1 

Gene Name

 SLC30A1 

Gene Synonyms/Alias

 ZNT1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
203	TSNSNGLKLDPADPE	ubiquitination	[1]
389	IIATAHIKCEDPTSY	ubiquitination	[2]
401	TSYMEVAKTIKDVFH	ubiquitination	[1]
427	EFASVGSKSSVVPCE	ubiquitination	[1, 2]
444	CRTQCALKQCCGTLP	ubiquitination	[2, 3]
457	LPQAPSGKDAEKTPA	ubiquitination	[2]
461	PSGKDAEKTPAVSIS	ubiquitination	[2]
478	ELSNNLEKKPRRTKA	ubiquitination	[2]
501	EIKNMPNKQPESSL*	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May be involved in zinc transport out of the cell. 

Sequence Annotation

 REGION 146 158 6 X 2 AA approximate repeats of H-G.
 MOD_RES 506 506 Phosphoserine.
 CARBOHYD 299 299 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 507 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030315; C:T-tubule; ISS:BHF-UCL.
 GO:0019855; F:calcium channel inhibitor activity; ISS:BHF-UCL.
 GO:0005385; F:zinc ion transmembrane transporter activity; IEA:Compara.
 GO:0070574; P:cadmium ion transmembrane transport; ISS:BHF-UCL.
 GO:0070509; P:calcium ion import; IEA:Compara.
 GO:0006874; P:cellular calcium ion homeostasis; ISS:BHF-UCL.
 GO:0006882; P:cellular zinc ion homeostasis; ISS:BHF-UCL.
 GO:0071585; P:detoxification of cadmium ion; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0090281; P:negative regulation of calcium ion import; ISS:BHF-UCL.
 GO:0046929; P:negative regulation of neurotransmitter secretion; ISS:BHF-UCL.
 GO:0071584; P:negative regulation of zinc ion transmembrane import; ISS:BHF-UCL.
 GO:0006829; P:zinc ion transport; ISS:BHF-UCL. 

Interpro

 IPR002524; Cation_efflux.
 IPR027469; Cation_efflux_TMD. 

Pfam

 PF01545; Cation_efflux 

SMART

  

PROSITE

  

PRINTS