| Tag | Content |
|---|
| CPLM ID | CPLM-001429 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Coagulation factor X |
Protein Synonyms/Alias | Stuart factor; Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain |
Gene Name | F10 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 326 | DIAVLRLKTPITFRM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. |
Sequence Annotation | DOMAIN 41 85 Gla.
DOMAIN 86 122 EGF-like 1; calcium-binding (Potential).
DOMAIN 125 165 EGF-like 2.
DOMAIN 232 464 Peptidase S1.
ACT_SITE 273 273 Charge relay system (By similarity).
ACT_SITE 319 319 Charge relay system (By similarity).
ACT_SITE 416 416 Charge relay system (By similarity).
MOD_RES 46 46 4-carboxyglutamate (By similarity).
MOD_RES 47 47 4-carboxyglutamate (By similarity).
MOD_RES 54 54 4-carboxyglutamate (By similarity).
MOD_RES 56 56 4-carboxyglutamate (By similarity).
MOD_RES 59 59 4-carboxyglutamate (By similarity).
MOD_RES 60 60 4-carboxyglutamate (By similarity).
MOD_RES 65 65 4-carboxyglutamate (By similarity).
MOD_RES 66 66 4-carboxyglutamate (By similarity).
MOD_RES 69 69 4-carboxyglutamate (By similarity).
MOD_RES 72 72 4-carboxyglutamate (By similarity).
MOD_RES 75 75 4-carboxyglutamate (By similarity).
MOD_RES 79 79 4-carboxyglutamate (By similarity).
MOD_RES 103 103 (3R)-3-hydroxyaspartate (By similarity).
CARBOHYD 187 187 N-linked (GlcNAc...).
CARBOHYD 218 218 N-linked (GlcNAc...) (Potential).
DISULFID 57 62 By similarity.
DISULFID 90 101 By similarity.
DISULFID 95 110 By similarity.
DISULFID 112 121 By similarity.
DISULFID 129 140 By similarity.
DISULFID 136 149 By similarity.
DISULFID 151 164 By similarity.
DISULFID 172 339 Interchain (between light and heavy
DISULFID 238 243 By similarity.
DISULFID 258 274 By similarity.
DISULFID 387 401 By similarity.
DISULFID 412 440 By similarity. |
Keyword | Blood coagulation; Calcium; Cleavage on pair of basic residues; Complete proteome; Disulfide bond; EGF-like domain; Gamma-carboxyglutamic acid; Glycoprotein; Hemostasis; Hydrolase; Hydroxylation; Protease; Reference proteome; Repeat; Secreted; Serine protease; Signal; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 481 AA |
Protein Sequence | MGSPVQLSLL CVVLASLLLP GKGVFINRER ANNVLARTRR ANSFFEEFKK GNLERECMEE 60
ICSYEEVREI FEDDEKTKEY WTKYKDGDQC ESSPCQNQGA CRDGIGGYTC TCSEGFEGKN 120
CELFVRKLCR LDNGDCDQFC REEQNSVVCS CASGYFLGND GKSCISTAPF PCGKITTGRR 180
KRSVALNTSD SELDLEDALL DEDFLSPTEN PIELLNLNET QPERSSDDLV RIVGGRECKD 240
GECPWQALLI NEDNEGFCGG TILNEFYILT AAHCLHQARR FKVRVGDRNT EKEEGNEMVH 300
EVDVVIKHNK FQRDTYDYDI AVLRLKTPIT FRMNVAPACL PQKDWAESTL MTQKTGIVSG 360
FGRTHEKGRQ SNILKMLEVP YVDRNTCKLS TSFSITQNMF CAGYEAKLED ACQGDSGGPH 420
VTRFKNTYYV TGIVSWGEGC ARKGKYGIYT KVTTFLKWID RSMKARVGPT AETPRTAGPP 480
N 481 |
Gene Ontology | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. GO:0007596; P:blood coagulation; IEA:UniProtKB-KW. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |