Tag | Content |
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CPLM ID | CPLM-009692 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Potassium voltage-gated channel subfamily A member 2 |
Protein Synonyms/Alias | MK2; Voltage-gated potassium channel subunit Kv1.2 |
Gene Name | Kcna2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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49 | LRFETQLKTLAQFPE | ubiquitination | [1] | 63 | ETLLGDPKKRMRYFD | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Regulates neuronal excitability and is involved in non-rapid eye movement (NREM) sleep. |
Sequence Annotation | MOTIF 374 379 Selectivity filter (By similarity). MOTIF 497 499 PDZ-binding (By similarity). MOD_RES 421 421 Phosphothreonine. MOD_RES 429 429 Phosphotyrosine. MOD_RES 433 433 Phosphothreonine. MOD_RES 449 449 Phosphoserine; by PKA (Potential). LIPID 244 244 S-palmitoyl cysteine (Potential). CARBOHYD 38 38 N-linked (GlcNAc...) (Potential). CARBOHYD 207 207 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Glycoprotein; Ion channel; Ion transport; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 499 AA |
Protein Sequence | MTVATGDPVD EAAALPGHPQ DTYDPEADHE CCERVVINIS GLRFETQLKT LAQFPETLLG 60 DPKKRMRYFD PLRNEYFFDR NRPSFDAILY YYQSGGRLRR PVNVPLDIFS EEIRFYELGE 120 EAMEMFREDE GYIKEEERPL PENEFQRQVW LLFEYPESSG PARIIAIVSV MVILISIVSF 180 CLETLPIFRD ENEDMHGGGV TFHTYSNSTI GYQQSTSFTD PFFIVETLCI IWFSFEFLVR 240 FFACPSKAGF FTNIMNIIDI VAIIPYFITL GTELAEKPED AQQGQQAMSL AILRVIRLVR 300 VFRIFKLSRH SKGLQILGQT LKASMRELGL LIFFLFIGVI LFSSAVYFAE ADERDSQFPS 360 IPDAFWWAVV SMTTVGYGDM VPTTIGGKIV GSLCAIAGVL TIALPVPVIV SNFNYFYHRE 420 TEGEEQAQYL QVTSCPKIPS SPDLKKSRSA STISKSDYME IQEGVNNSNE DFREENLKTA 480 NCTLANTNYV NITKMLTDV 499 |
Gene Ontology | GO:0044224; C:juxtaparanode region of axon; IDA:BHF-UCL. GO:0008076; C:voltage-gated potassium channel complex; IDA:BHF-UCL. GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome. GO:0015271; F:outward rectifier potassium channel activity; IEA:Compara. GO:0021633; P:optic nerve structural organization; IMP:MGI. GO:0051260; P:protein homooligomerization; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |