CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017141
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Netrin receptor UNC5B 
Protein Synonyms/Alias
 Protein unc-5 homolog 2; Protein unc-5 homolog B; p53-regulated receptor for death and life protein 1 
Gene Name
 UNC5B 
Gene Synonyms/Alias
 P53RDL1; UNC5H2; UNQ1883/PRO4326 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
427GFHPVNFKTARPSNPubiquitination[1]
465ALQDSTDKIPMTNSPubiquitination[1, 2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. 
Sequence Annotation
 DOMAIN 48 145 Ig-like.
 DOMAIN 147 242 Ig-like C2-type.
 DOMAIN 246 300 TSP type-1 1.
 DOMAIN 302 354 TSP type-1 2.
 DOMAIN 544 688 ZU5.
 DOMAIN 865 943 Death.
 REGION 689 838 UPA domain (By similarity).
 REGION 707 725 Interaction with DCC (By similarity).
 LIPID 403 403 S-palmitoyl cysteine.
 CARBOHYD 222 222 N-linked (GlcNAc...) (Potential).
 CARBOHYD 347 347 N-linked (GlcNAc...) (Potential).
 DISULFID 69 128 By similarity.
 DISULFID 174 225 By similarity.
 DISULFID 258 295 By similarity.
 DISULFID 262 299 By similarity.
 DISULFID 273 285 By similarity.  
Keyword
 Alternative splicing; Apoptosis; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Immunoglobulin domain; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 945 AA 
Protein Sequence
MGARSGARGA LLLALLLCWD PRLSQAGTDS GSEVLPDSFP SAPAEPLPYF LQEPQDAYIV 60
KNKPVELRCR AFPATQIYFK CNGEWVSQND HVTQEGLDEA TGLRVREVQI EVSRQQVEEL 120
FGLEDYWCQC VAWSSAGTTK SRRAYVRIAY LRKNFDQEPL GKEVPLDHEV LLQCRPPEGV 180
PVAEVEWLKN EDVIDPTQDT NFLLTIDHNL IIRQARLSDT ANYTCVAKNI VAKRRSTTAT 240
VIVYVNGGWS SWAEWSPCSN RCGRGWQKRT RTCTNPAPLN GGAFCEGQAF QKTACTTICP 300
VDGAWTEWSK WSACSTECAH WRSRECMAPP PQNGGRDCSG TLLDSKNCTD GLCMQNKKTL 360
SDPNSHLLEA SGDAALYAGL VVAIFVVVAI LMAVGVVVYR RNCRDFDTDI TDSSAALTGG 420
FHPVNFKTAR PSNPQLLHPS VPPDLTASAG IYRGPVYALQ DSTDKIPMTN SPLLDPLPSL 480
KVKVYSSSTT GSGPGLADGA DLLGVLPPGT YPSDFARDTH FLHLRSASLG SQQLLGLPRD 540
PGSSVSGTFG CLGGRLSIPG TGVSLLVPNG AIPQGKFYEM YLLINKAEST LPLSEGTQTV 600
LSPSVTCGPT GLLLCRPVIL TMPHCAEVSA RDWIFQLKTQ AHQGHWEEVV TLDEETLNTP 660
CYCQLEPRAC HILLDQLGTY VFTGESYSRS AVKRLQLAVF APALCTSLEY SLRVYCLEDT 720
PVALKEVLEL ERTLGGYLVE EPKPLMFKDS YHNLRLSLHD LPHAHWRSKL LAKYQEIPFY 780
HIWSGSQKAL HCTFTLERHS LASTELTCKI CVRQVEGEGQ IFQLHTTLAE TPAGSLDTLC 840
SAPGSTVTTQ LGPYAFKIPL SIRQKICNSL DAPNSRGNDW RMLAQKLSMD RYLNYFATKA 900
SPTGVILDLW EALQQDDGDL NSLASALEEM GKSEMLVAVA TDGDC 945 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; TAS:Reactome.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR000884; Thrombospondin_1_rpt.
 IPR000906; ZU5. 
Pfam
 PF00531; Death
 PF07679; I-set
 PF00090; TSP_1
 PF00791; ZU5 
SMART
 SM00005; DEATH
 SM00408; IGc2
 SM00209; TSP1
 SM00218; ZU5 
PROSITE
 PS50017; DEATH_DOMAIN
 PS50835; IG_LIKE
 PS50092; TSP1
 PS51145; ZU5 
PRINTS