| Tag | Content |
|---|
| CPLM ID | CPLM-016901 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | N-acetyltransferase ESCO2 |
Protein Synonyms/Alias | Establishment of cohesion 1 homolog 2; ECO1 homolog 2 |
Gene Name | Esco2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 369 | RDTNKGGKDQLVIDA | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (By similarity). |
Sequence Annotation | ZN_FING 384 408 CCHH-type.
MOD_RES 41 41 Phosphoserine (By similarity).
MOD_RES 85 85 Phosphoserine (By similarity). |
Keyword | Acyltransferase; Cell cycle; Chromosome; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transferase; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 592 AA |
Protein Sequence | MMATCTPRKR KRYTLNADND DSLLTDISSS KLRCAENLFP SPNKKHNYQS SVQKEDKSCS 60
HQLHFPSSPL KTTENSRFSF ANHSSLFKPA MSTVSFYSKE KYYLNPLERK LIRECRSICL 120
ATESGDKPIP SVTENIQRKP VCTKKNKKKQ KSLTAKYQPN YKHIKSKSRN LKNSKPNQVT 180
YKPVVDQENS CFPAKNYPNS PPRVLSQKIK PQVTLQGGAA FFVRKRNSLK KLPLEDKPLL 240
LQKNLPEVPE GAPEAKQIPK SLLVDEKSSV KVQNARSKNE EKLRKNPSGA VVSSKECNLD 300
KHDFPSENSL DENKTISPES VYPIFNVSSV NTKRPEEQSS VGSTACTNFL KQTNVPKNIN 360
SRDTNKGGKD QLVIDAGQKH FGTTVCKSCG MIYTASNPED EIQHLQHHHR FLEGIKFVGW 420
KRERVVAEFW DGKIVLVLPR DPSYAIKKVE DVQELVDLEL GFQQTVPVCP DKTKTFLFID 480
EKRVVGCLIA EPIKQAFRVL SEPSASKECS RAWRCSDVPE PAICGISRIW VFRLKRRKRI 540
ARRLVDTVRN CFMFGCFLST NEIAFSDPTP DGKLFATKYC NTPNFLVYNF HN 592 |
Gene Ontology | GO:0000785; C:chromatin; ISS:UniProtKB. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW. GO:0007049; P:cell cycle; IEA:UniProtKB-KW. GO:0034421; P:post-translational protein acetylation; IEA:Compara. GO:0006275; P:regulation of DNA replication; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |