CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037370
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Solute carrier family 12 member 1 
Protein Synonyms/Alias
  
Gene Name
 SLC12A1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
741KKQAWLIKNKIKAFYubiquitination[1]
743QAWLIKNKIKAFYAAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1099 AA 
Protein Sequence
MSLNNSSNVF LDSVPSNTNR FQVSVINENH ESSAAADDNT DPPHYEETSF GDEAQKRLRI 60
SFRPGNQECY DNFLQSGETA KTDASFHAYD SHTNTYYLQT FGHNTMDAVP KIEYYRNTGS 120
ISGPKVNRPS LLEIHEQLAK NVAVTPSSAD RVANGDGIPG DEQAENKEDD QAGVVKFGWV 180
KGVLVRCMLN IWGVMLFIRL SWIVGEAGIG LGVIIIGLSV VVTTLTGISM SAICTNGVVR 240
GGGAYYLISR SLGPEFGGSI GLIFAFANAV AVAMYVVGFA ETVVDLLKES DSMMVDPTND 300
IRIIGSITVV ILLGISVAGM EWEAKAQVIL LVILLIAIAN FFIGTVIPSN NEKKSRGFFN 360
YQASIFAENF GPRFTKGEGF FSVFAIFFPA ATGILAGANI SGDLEDPQDA IPRGTMLAIF 420
ITTVAYLGVA ICVGACVVRD ATGNMNDTII SGMNCNGSAA CGLGYDFSRC RHEPCQYGLM 480
NNFQVMSMVS GFGPLITAGI FSATLSSALA SLVSAPKVFQ ALCKDNIYKA LQFFAKGYGK 540
NNEPLRGYIL TFLIAMAFIL IAELNTIAPI ISNFFLASYA LINFSCFHAS YAKSPGWRPA 600
YGIYNMWVSL FGAVLCCAVM FVINWWAAVI TYVIEFFLYV YVTCKKPDVN WGSSTQALSY 660
VSALDNALEL TTVEDHVKNF RPQCIVLTGG PMTRPALLDI THAFTKNSGL CICCEVFVGP 720
RKLCVKEMNS GMAKKQAWLI KNKIKAFYAA VAADCFRDGV RSLLQASGLG RMKPNTLVIG 780
YKKNWRKAPL TEIENYVGII HDAFDFEIGV VIVRISQGFD ISQVLQVQEE LERLEQERLA 840
LEATIKDNEC EEESGGIRGL FKKAGKLNIT KTTPKKDGSI NTSQSMHVGE FNQKLVEAST 900
QFKKKQEKGT IDVWWLFDDG GLTLLIPYIL TLRKKWKDCK LRIYVGGKIN RIEEEKIVMA 960
SLLSKFRIKF ADIHIIGDIN IRPNKESWKV FEEMIEPYRL HESCKDLTTA EKLKRETPWK 1020
ITDAELEAVK EKSYRQVRLN ELLQEHSRAA NLIVLSLPVA RKGSISDLLY MAWLEILTKN 1080
LPPVLLVRGN HKNVLTFYS 1099 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0015377; F:cation:chloride symporter activity; IEA:InterPro.
 GO:0048878; P:chemical homeostasis; IEA:Compara.
 GO:0007588; P:excretion; IEA:Compara.
 GO:0001822; P:kidney development; IEA:Compara. 
Interpro
 IPR004841; AA-permease_dom.
 IPR013612; AA_permease_N.
 IPR002443; Na/K/Cl_cotranspt.
 IPR002445; Na/K/Cl_cotranspt2.
 IPR004842; Na/K/Cl_cotransptS. 
Pfam
 PF00324; AA_permease
 PF08403; AA_permease_N 
SMART
  
PROSITE
  
PRINTS
 PR01207; NAKCLTRNSPRT.
 PR01209; NAKCLTRSPRT2.