UniProt Accession

 C9JAM9_HUMAN; C9JAM9 

Genbank Protein ID

 AC076966 

Genbank Nucleotide ID

  

Protein Name

 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 

Protein Synonyms/Alias

  

Gene Name

 PIK3CA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
100	RLFQPFLKVIEPVGN	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 118 AA 

Protein Sequence

Gene Ontology

 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:Compara.
 GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IEA:Compara.
 GO:0030295; F:protein kinase activator activity; IEA:Compara.
 GO:0006006; P:glucose metabolic process; IEA:Compara.
 GO:0044029; P:hypomethylation of CpG island; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0036092; P:phosphatidylinositol-3-phosphate biosynthetic process; IEA:GOC.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0043491; P:protein kinase B signaling cascade; IEA:Compara.
 GO:0006468; P:protein phosphorylation; IEA:Compara.
 GO:2000653; P:regulation of genetic imprinting; IEA:Compara.
 GO:0040014; P:regulation of multicellular organism growth; IEA:Compara. 

Interpro

 IPR003113; PI3K_adapt-bd_dom. 

Pfam

 PF02192; PI3K_p85B 

SMART

 SM00143; PI3K_p85B 

PROSITE

 PS51544; PI3K_ABD 

PRINTS