CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018493
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone deacetylase 11 
Protein Synonyms/Alias
 HD11 
Gene Name
 Hdac11 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
237EDEEYLEKVERNVRRubiquitination[1]
280ISPAGIVKRDEVVFRubiquitination[1]
306VTSGGYQKRTARIIAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). 
Sequence Annotation
 REGION 14 318 Histone deacetylase.
 ACT_SITE 143 143 By similarity.  
Keyword
 Chromatin regulator; Complete proteome; Hydrolase; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 347 AA 
Protein Sequence
MPHATQLYQH VPEKRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK EEKLLSDGML 60
VEAREASEED LLVVHTRRYL NELKWSFVVA TITEIPPVIF LPNFLVQRKV LRPLRTQTGG 120
TIMAGKLAVE RGWAINVGGG FHHCSSDRGG GFCAYADITL AIKFLFERVE GISRATIIDL 180
DAHQGNGHER DFMGDKRVYI MDVYNRHIYP GDRFAKEAIR RKVELEWGTE DEEYLEKVER 240
NVRRSLQEHL PDVVVYNAGT DVLEGDRLGG LSISPAGIVK RDEVVFRVVR AHDIPILMVT 300
SGGYQKRTAR IIADSILNLH DLGLIGPEFP CVSAQNSGIP LLSCAVP 347 
Gene Ontology
 GO:0005737; C:cytoplasm; TAS:UniProtKB.
 GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0004407; F:histone deacetylase activity; TAS:UniProtKB.
 GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.
 GO:0097372; F:NAD-dependent histone deacetylase activity (H3-K18 specific); IEA:EC.
 GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.
 GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
 GO:0008134; F:transcription factor binding; TAS:UniProtKB.
 GO:0070932; P:histone H3 deacetylation; IEA:GOC.
 GO:0070933; P:histone H4 deacetylation; IEA:GOC.
 GO:0014003; P:oligodendrocyte development; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000286; His_deacetylse.
 IPR023801; His_deacetylse_dom. 
Pfam
 PF00850; Hist_deacetyl 
SMART
  
PROSITE
  
PRINTS
 PR01270; HDASUPER.