UniProt Accession

 LIPH_HUMAN; Q8WWY8; A2IBA7; Q8TEC7 

Genbank Protein ID

 AY036912; AY093498; EF186229; AK074229; AK122651; CH471052; BC064941 

Genbank Nucleotide ID

 AAK63178.1; AAM18803.1; ABM67095.1; BAB85023.1; BAG53642.1; EAW78218.1; AAH64941.1 

Protein Name

 Lipase member H 

Protein Synonyms/Alias

 LIPH; LPD lipase-related protein; Membrane-associated phosphatidic acid-selective phospholipase A1-alpha; mPA-PLA1 alpha; Phospholipase A1 member B 

Gene Name

 LIPH 

Gene Synonyms/Alias

 LPDLR; MPAPLA1; PLA1B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
49	RLMLYTRKNLTCAQT	ubiquitination	[1]
69	FGNLNVTKKTTFIVH	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). 

Sequence Annotation

 ACT_SITE 154 154 Nucleophile.
 ACT_SITE 178 178 Charge relay system (By similarity).
 ACT_SITE 248 248 Charge relay system (By similarity).
 CARBOHYD 50 50 N-linked (GlcNAc...) (Potential).
 CARBOHYD 66 66 N-linked (GlcNAc...) (Potential).
 CARBOHYD 357 357 N-linked (GlcNAc...) (Potential).
 DISULFID 233 246 By similarity.
 DISULFID 270 281 By similarity.
 DISULFID 284 292 By similarity.
 DISULFID 427 446 By similarity.  

Keyword

 Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Heparin-binding; Hydrolase; Hypotrichosis; Lipid degradation; Lipid metabolism; Membrane; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 451 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0008201; F:heparin binding; IDA:UniProtKB.
 GO:0004620; F:phospholipase activity; IDA:UniProtKB.
 GO:0016042; P:lipid catabolic process; IDA:UniProtKB. 

Interpro

 IPR000734; Lipase.
 IPR013818; Lipase_N.
 IPR016272; Lipoprotein_lipase_LIPH. 

Pfam

 PF00151; Lipase 

SMART

  

PROSITE

 PS00120; LIPASE_SER 

PRINTS

 PR00821; TAGLIPASE.