| Tag | Content |
|---|
| CPLM ID | CPLM-017860 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Interferon regulatory factor 2-binding protein 1 |
Protein Synonyms/Alias | IRF-2-binding protein 1; IRF-2BP1; Probable E3 ubiquitin-protein ligase IRF2BP1 |
Gene Name | Irf2bp1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 314 | ALASSGFKYLEYERR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation (By similarity). |
Sequence Annotation | ZN_FING 503 550 RING-type; degenerate.
REGION 503 550 Cys-rich.
MOD_RES 66 66 Phosphoserine (By similarity).
MOD_RES 125 125 Phosphoserine (By similarity).
MOD_RES 186 186 Phosphoserine (By similarity).
MOD_RES 384 384 Phosphoserine.
MOD_RES 421 421 Phosphoserine (By similarity).
MOD_RES 436 436 Phosphoserine.
MOD_RES 453 453 Phosphoserine.
MOD_RES 457 457 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Ligase; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 584 AA |
Protein Sequence | MASVQASRRQ WCYLCDLPKM PWAMVWDFSE AVCRGCVNFE GADRIELLID AARQLKRSHV 60
LPEGRSPGPP ALKHPTSKDL ASTGSQGSQL PPPQAQAQPS GTGGSVSGPD RYDRATSSSR 120
LALPSPALEY TLGSRLANGL GREEAVAEGA RRALLGSIPS LMPPGLLAAA VSGLGGRALT 180
LAPGLSPARP LFGSDFEKEK QQRNADCLAE LNEAMRGRAE EWHGRPKAVR EQLLALSACA 240
PFNVRFKKDH GLVGRVFAFD ATARPPGYEF ELKLFTEYPC GSGNVYAGVL AVARQMFHDA 300
LREPGKALAS SGFKYLEYER RHGSGEWRQL GELLTDGVRS FREPAPAEAL PQQYPEPAPA 360
ALCGPPPRAP SRNLAPTPRR RKASPEPEGE TAGKMTTEEQ QQRHWVAPGG PYSSETPGVP 420
SPIAALKNVA EALGHSPKDP GGGGGSVRAG GASPAASSTT QPPAQHRLVA RNGEAEVSPT 480
AGAEAVSGGG SGTGATPGAP LCCTLCRERL EDTHFVQCPS VPGHKFCFPC SREFIKAQGP 540
AGEVYCPSGD KCPLVGSSVP WAFMQGEIAT ILAGDIKVKK ERDP 584 |
Gene Ontology | GO:0005634; C:nucleus; ISA:MGI. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0003714; F:transcription corepressor activity; ISA:MGI. GO:0008134; F:transcription factor binding; ISA:MGI. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISA:MGI. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |