UniProt Accession

 ALLR_ECOLI; P0ACN4; P77734; Q2MBS2 

Genbank Protein ID

 U89024; U82664; U00096; AP009048 

Genbank Nucleotide ID

 AAB93847.1; AAB40259.1; AAC73608.1; BAE76284.1 

Protein Name

 HTH-type transcriptional repressor AllR 

Protein Synonyms/Alias

 Negative regulator of allantoin and glyoxylate utilization operons 

Gene Name

 allR 

Gene Synonyms/Alias

 glxA3; ybbU; b0506; JW0494 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
19	QAEPVAQKGAQALER	acetylation	[1]
136	LIGQLECKSMVRMCA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region. Binding to DNA is abolished by glyoxylate. 

Sequence Annotation

 DOMAIN 21 83 HTH iclR-type.
 DOMAIN 98 267 IclR-ED.
 DNA_BIND 43 62 H-T-H motif (Potential).
 REGION 154 156 Glyoxylate binding.
 REGION 234 236 Glyoxylate binding.
 BINDING 207 207 Glyoxylate.
 BINDING 217 217 Glyoxylate.  

Keyword

 3D-structure; Complete proteome; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 271 AA 

Protein Sequence

Gene Ontology

 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:EcoCyc.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR014757; Tscrpt_reg_IclR_C.
 IPR005471; Tscrpt_reg_IclR_N.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF09339; HTH_IclR
 PF01614; IclR 

SMART

 SM00346; HTH_ICLR 

PROSITE

 PS51077; HTH_ICLR
 PS51078; ICLR_ED 

PRINTS