UniProt Accession

 AK1CL_MOUSE; Q91WR5; Q6P8V0; Q9CX32 

Genbank Protein ID

 AB178898; AY742217; AK020439; BC013531; BC061057; BC091761 

Genbank Nucleotide ID

 BAD18929.1; AAW65159.1; BAB32101.1; AAH13531.1; AAH61057.1; AAH91761.1 

Protein Name

 Aldo-keto reductase family 1 member C21 

Protein Synonyms/Alias

 17-alpha-hydroxysteroid dehydrogenase; 17-alpha-HSD; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-hydroxysteroid dehydrogenase; Dihydrodiol dehydrogenase type 1; DD1; Dihydrodiol dehydrogenase type 3; DD3 

Gene Name

 Akr1c21 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
39	SKAKELTKIAIDAGF	ubiquitination	[1]
161	CKDAGLTKSIGVSNF	ubiquitination	[1]
179	QLEMILNKPGLKYKP	ubiquitination	[1]
185	NKPGLKYKPVCNQVE	ubiquitination	[1]
246	PVLGSMAKKYNRTPA	ubiquitination	[1]
273	VVLNTSLKEERIKEN	ubiquitination	[1]
278	SLKEERIKENMQVFE	ubiquitination	[1]
294	QLSSEDMKVLDGLNR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into androsterone. Has lower 3-alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha- hydroxysteroids, 17-ketosteroids, 3-alpha hydroxysteroids and 3- ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17- alpha-hydroxysteroids. Likewise, reduction of 3-ketosteroids yields only 3-alpha-hydroxysteroids. 

Sequence Annotation

 NP_BIND 13 24 NADP.
 NP_BIND 166 167 NADP.
 NP_BIND 216 224 NADP.
 NP_BIND 270 279 NADP.
 ACT_SITE 55 55 Proton donor.
 BINDING 31 31 Substrate.
 BINDING 50 50 NADP.
 BINDING 117 117 Substrate.
 MOD_RES 88 88 Phosphothreonine.
 MOD_RES 89 89 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Lipid metabolism; NADP; Oxidoreductase; Phosphoprotein; Reference proteome; Steroid metabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004033; F:aldo-keto reductase (NADP) activity; ISA:MGI.
 GO:0047023; F:androsterone dehydrogenase activity; IDA:UniProtKB.
 GO:0006694; P:steroid biosynthetic process; ISA:MGI. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 

PRINTS

 PR00069; ALDKETRDTASE.