N-ethylmaleimide-sensitive fusion protein; NEM-sensitive fusion protein; Vesicular-fusion protein NSF
Gene Name
Nsf
Gene Synonyms/Alias
Erg1
Created Date
July 27, 2013
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Lysine Modification
Position
Peptide
Type
References
198
SSLNLIGKAKTKENR
ubiquitination
[1]
462
RHIKASTKVEVDMEK
ubiquitination
[1]
469
KVEVDMEKAESLQVT
ubiquitination
[1]
529
ELLVQQTKNSDRTPL
ubiquitination
[1]
Reference
[1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
Functional Description
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling.
Sequence Annotation
NP_BIND 505 510 ATP (By similarity). NP_BIND 545 552 ATP (By similarity). METAL 550 550 Magnesium (By similarity). MOD_RES 259 259 Phosphotyrosine (By similarity). MOD_RES 569 569 Phosphoserine; by CDK16 (By similarity).
Keyword
ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport.