CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038392
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Akap13 
Protein Synonyms/Alias
  
Gene Name
 Akap13 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
135DVNSLDEKVALAFRHubiquitination[1]
286NIQQQLMKTNLKQMDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2776 AA 
Protein Sequence
MKLSPQQAPL YGDCVVTVLL AEEDKVEDDA IFYLIFSGST LYHCTSTRKV SSDTLETIAP 60
GHDCCETVKV LLCASREGLP VFVVAEEDFH FVQDEAYDAA QFLATSAGNQ QALNFTRFLD 120
RSGPPSRDVN SLDEKVALAF RHLKLPAEWN VLGTDHTLHD GGPRETLMHF AVRLGLLRLT 180
WFLLQKPGGR GALSIHNKEG ATPVSLALER GYHELHQLLT EENAGEPDSW SSLSYEIPYG 240
DCSVRHHREL DIYTLTSESE SHREPHGDSC TGHISKLMNI QQQLMKTNLK QMDNLMPLMV 300
TAQDSSCVPS VPETDGLFLP CVPEPSDHQH PPFEETKSTL CCQRSPGRMA ESSCDLSSMV 360
EEENVICSHK KNKDVGRKGE EAEPASAMDS GSASHQDSCL QSVPDCGVKG REGLPSCGNR 420
NEVTGTNYSG VATCQQPLSS RSSVLQDAMV TEPDACQHSS GRELPDSSST DVGAPEKAGE 480
LEHSLLTPDA TTQNNKPQVG EGTKERLENS DSSTTETTAV QVLSEPMEKA DITNHVFATS 540
AVGVNTPAEA SPALSSEEIP TEKPGMETQE RGCEGGTTSD QSSPVLPAAA IENKVLGGQE 600
PDTSIAGFCK TASPLDLTMP GPSSDGMPEQ NSESHARPAQ SLSGQALLCS TAEAGTPSAE 660
ATHQPSTVTS SGRLEECGSG KASLPESTMV QPSTQELCTT LCPEDPQADT VTSDTVKNTQ 720
KSVGVCHLCV SDAKNQGNGL KQDTPLTNVL EDVPRLPSVV SQTEKELAPD QVSPPASSFS 780
LASSPESESV TKDDALSLVP SQKEKGTATP QLHRTTACRD GPDGRDLSDT DKVGDGATDP 840
PPSSAVELRT SMGNTSPVGI GGEQEGSSPT ATLEVLSDSL LHNVDKAALV SDFTLPEEGV 900
SVVVPESSTA LGQDGKDRAM SCSSVKEDVH SSEMSREDQR TPPSGQEIPG LCEKPMSALC 960
AEEKAQQHTP SACLKTETKD IKEVAPQVSL LTEGGAAKSL VPPRTSLSAD SKQKASSTEQ 1020
SGSSLLPSGL PGASEALHCN QPSALDVVVE NTQFQGETNA CEVSRSAMED VTVADASPAT 1080
AEPRKKDASH CIKDIPISEL LNQEKQMTPS LPEAFLDKGV TDLQEVITPE IEPLDCKRET 1140
LEGTDLNCAT SNSKETPIEK PMQPLARDLP TETGLSVINN NVPQADMKQV AQASIPAEES 1200
NATTVSTQAA DVPTRADSIE ETATRIVEAV IRQVRASNAL MAKVETQNPS LSSPETKQLE 1260
NAYTESACAF LPGETPQIEK THEDTTGQCG AETEEPEKII LPESAPGKQG KMPDTRTGDE 1320
VDLLSRISAA SEEEAVGNGA ATPKMKQGPG TQAINRESWC AIEPCPEAAS LLASKQSSEC 1380
RSFIDVGLGT ECASKEGMLQ RVSGSESDLF HSPSDEMDSI IFPKPEEEQL LCDTTGSSSS 1440
TDDTASLDRH SSHGSDVSLP QTSKLNRSRN HQSANGFFSP GVEAPESRES ESEPAGSGEM 1500
EEEEMDSITE VPANCSFLRS SMRSLSPFRR HSWGPGKNAA SDAEMNQRSS MRALGHVVRR 1560
PPIHRRSFSL EGLTGGGVGN KPSSSLEMSS ANSSELRNPF GGEEQRNSLM SLSEEHLEPD 1620
QRQHHRMFDQ QTCYRSKQQG FNYCTSAISS PLTKSISLMT ISHPGLDSSR PFHSTSANLT 1680
ESITEENCNF LPPSPSKKNF EEKSGTKVSR TFSYIRNKMS SSKKSKEKEK EKDKIKEKEK 1740
DSKEKEKDKK TLNGHTFSPI PIVGPISCSQ CMKPFTNKDA YTCAGCGAFV HKGCRENLAS 1800
CAKVKMKQPK GSLQAHDTSS LPTVIMRNKS SQPKERPRSA VLLADEATAA PMFTNRRSQQ 1860
SVSLSKSVSI QNITGVGNDE NMSNTWKFLS HSTDSLNKIC KVNESTESLT DEGVGTDMNE 1920
GQLMGDFESD SKQLEAESWS RTVDSKFLKQ QKKDVVKRQE VIYELMQTEL HHIRTLKIMS 1980
DVYSRGMMTD LLFEQQMVEK LFPCLDELIS IHSQFFQRIL ERKKESLVDK SEKNFLIKRI 2040
GDVLVSQFSG ESAERLKKTY GKFCGQHNQS VNYFKDLYTK DKRFQAFVKK KMSSSVVRRL 2100
GIPECILLVT QRITKYPVLF QRILQCTKDN EVEQEDLTQS LSLVKDVIGA VDSKVASYEK 2160
KVRLGEIYTK TDSKSIMRMK SGQMFAKEDL RRKKLVRDGS VFLKSTTGRL KEVQAVLLTD 2220
ILVFLQEKDQ KYVFASLDHK STVISLKKLI VREVAHEEKG LFLISMGVKD PEMVEVHASS 2280
REERNSWIQI IQDTINSLNR DEDEGIPSEN EEEKKLLDTK ARELKEQLQQ KDQQILLLLE 2340
EKEMIFRDMT ECSTPLPEDC SPTHSPRVLF RSNTEEALKG GPLMKSAINE VEILQSLVSG 2400
SLGGTLGQSI SSPVEQEVMA APISLPRRAE TFGGFDCHQM NASKGGEKEE GDDGQDLRRT 2460
ESDSGLKKGG NGNLVFMLKR NSEQVVQSIV HLHELLSMLQ GVVLQQDSYI EDQKLVLTEK 2520
VLTRSASRPS SLIEQEKQRS LEKQRQDLAN LQKQQAQHLE EKRRREREWE AREQELRDRE 2580
AKLAEREETV RRRQQDLERD REELQQKKGT YQCDLERLRA AQKQLEREQE QLRRDTERLS 2640
QRQMDQNLCQ VSNKHGRLMR IPSFLPNSDE FSSPSAPSVT KSGSLDSELS VSPKRNSISR 2700
TQKDKGPFHI LGSASQTKVP EGQSQAPSST STSTRLFGLS KPKEKKEKKK KSKGSRTQPG 2760
DGPASEVPAE GEEIFC 2776 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:1900169; P:regulation of glucocorticoid mediated signaling pathway; IMP:MGI.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR015721; RhoGEF-like. 
Pfam
 PF00169; PH
 PF00621; RhoGEF 
SMART
 SM00109; C1
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS