| Tag | Content |
|---|
| CPLM ID | CPLM-013785 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Enolase-phosphatase E1 |
Protein Synonyms/Alias | 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; MASA homolog |
Gene Name | Enoph1 |
Gene Synonyms/Alias | Masa |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 180 | IDGHFDTKIGHKVES | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity). |
Sequence Annotation | REGION 150 151 Substrate binding (By similarity).
METAL 16 16 Magnesium (By similarity).
METAL 18 18 Magnesium; via carbonyl oxygen (By
METAL 209 209 Magnesium (By similarity).
BINDING 184 184 Substrate (By similarity). |
Keyword | Amino-acid biosynthesis; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Metal-binding; Methionine biosynthesis; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 261 AA |
Protein Sequence | MVVVSVPAEV TVILLDIEGT TTPIAFVKDI LFPYIKENVK EYLQTHWEEE ECQQDVSLLR 60
KQAEEDAHLD GAVPIPVASG GDVQQMIQAV VDNVSWQMSH DRKTTALKQL QGHMWKAAFT 120
AGRMKAEVFA DVVPAVRRWR EAGMKVYIYS SGSVEAQKLL FGHSTEGDIL ELIDGHFDTK 180
IGHKVESDSY RKIADSIGCS TNNILFLTDV TVEASAAEEA DVHVAVVVRP GNAGLTDDEK 240
TYYNLISSFS ELYLPSTQSK V 261 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0043874; F:acireductone synthase activity; ISS:UniProtKB. GO:0000287; F:magnesium ion binding; IEA:InterPro. GO:0008967; F:phosphoglycolate phosphatase activity; IEA:InterPro. GO:0019509; P:L-methionine salvage from methylthioadenosine; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |