UniProt Accession

 GCH1_YEAST; P51601; D6VV45 

Genbank Protein ID

 Z47201; X94314; Y07893; Z73052; AY692993; Z49756; BK006941 

Genbank Nucleotide ID

 CAA87397.1; CAA63975.1; CAA69198.1; CAA97297.1; AAT93012.1; CAA89826.1; DAA08356.1 

Protein Name

 GTP cyclohydrolase 1 

Protein Synonyms/Alias

 GTP cyclohydrolase I; GTP-CH-I 

Gene Name

 FOL2 

Gene Synonyms/Alias

 YGR267C; G9349 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
55	EETEEEEKERIQRIS	acetylation	[1]
90	DTPQRYAKAMLYFTK	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid. 

Sequence Annotation

 METAL 132 132 Zinc (By similarity).
 METAL 135 135 Zinc (By similarity).
 METAL 203 203 Zinc (By similarity).
 MOD_RES 15 15 Phosphothreonine.
 MOD_RES 23 23 Phosphoserine.  

Keyword

 Allosteric enzyme; Complete proteome; Folate biosynthesis; GTP-binding; Hydrolase; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 243 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003934; F:GTP cyclohydrolase I activity; IMP:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0035998; P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.
 GO:0009396; P:folic acid-containing compound biosynthetic process; IMP:SGD.
 GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. 

Interpro

 IPR001474; GTP_CycHdrlase_I.
 IPR020602; GTP_CycHdrlase_I/CN_OxRdtase.
 IPR018234; GTP_CycHdrlase_I_CS. 

Pfam

 PF01227; GTP_cyclohydroI 

SMART

  

PROSITE

 PS00859; GTP_CYCLOHYDROL_1_1
 PS00860; GTP_CYCLOHYDROL_1_2 

PRINTS