CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011208
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Translation machinery-associated protein 64 
Protein Synonyms/Alias
  
Gene Name
 TMA64 
Gene Synonyms/Alias
 YDR117C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
334LKNFVPYKLGCSKSAacetylation[1]
339PYKLGCSKSATESREubiquitination[2]
371YKPFNLAKDLLKEVNacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
  
Sequence Annotation
 DOMAIN 89 170 PUA.
 DOMAIN 363 446 SWIB.
 DOMAIN 475 547 SUI1.  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 565 AA 
Protein Sequence
MFKKEPHIKA LSNLKNSERK KLLQTFQKQT NNEEYSFRTS TIKQTNFNGQ KSVGTVYTDE 60
NNTPILFKEK HKEQLFPTVY SCWEYPALLP IVLTHGFVIE EHLFNGANLM ISGSIPPFDP 120
RCKIGTLCGI ASKQAPETVL AIGIVELDLP SFDKVIGETG VAVKIIHHFN DGLSKVFKMK 180
LEPPFVLSTQ SKDNNISSKQ IESSEQIKAV EKEQEDVKEA SVDVEEIAEV LDHFTVSDVD 240
YFITRALYYT LTQDKGLELP ISASNFISNH IMRNLPPIDH NEVNVKKTSW KKSAKFLKHF 300
EKEGFLKLKG KGDDLTIVGK NTDKDELKNF VPYKLGCSKS ATESRESTTS KEKTSGMMYS 360
LTLYKPFNLA KDLLKEVNLA SHTYYTSQDI RSAVSQYISV KNLADTKDKG KVIMDDLLFD 420
MVNKKKKVLN ASRIIARGEI LHPLLTNNFT EFYQIFKSDD TLLFKAPMKG SLPHIKIITE 480
MKIGRKVITR VSNFEVFQVD PESLAADLRK ICSGSTTISE SQTFKCAEVQ VQGPHGQSII 540
DHLNKLGIPS KWIDFENKLK KKKRK 565 
Gene Ontology
 GO:0003723; F:RNA binding; ISS:SGD.
 GO:0003743; F:translation initiation factor activity; IEA:InterPro. 
Interpro
 IPR002478; PUA.
 IPR015947; PUA-like_domain.
 IPR003121; SWIB_MDM2_domain.
 IPR001950; TIF_SUI1. 
Pfam
 PF01253; SUI1
 PF02201; SWIB 
SMART
  
PROSITE
 PS50890; PUA
 PS50296; SUI1 
PRINTS