CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040554
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 Usp9y 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
315SMIIKFLKNLASRIPacetylation[1]
1813WERECAIKFNDYFEFubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2556 AA 
Protein Sequence
MTITTRGSPV GENESQGQTS DGQPQPSFQQ NQISSSDSSN ETSPTTPPYE QGQGDAPPQH 60
EEEDPSFPHT DLAKLEDMIN RSRWVVPVLP KGELEVLLEA SIDLTKKGLD VKSEACQRFF 120
RDVLTVSFSK ILMDEAVSGW KFEIHRCIIN NTHRLVELCV AKLSQDWFPF LELLAIALNP 180
HCKFHVYNGA RPCESVSSSV QFPEDELFAC SPDLHSPKGW LVDLINTFGT LNGFQILHDR 240
FTSGSALNVQ TIAALIKPFG QCYEFLTQHT LRKYFIPVIE VVPQILQKLT NEELKKETKT 300
EVKNDTISMI IKFLKNLASR IPGQEETVKN LETFRLKMIL RLLQISSFNG KMNALNEINK 360
VLSSVSYYTH GHGNSEEEWL TVERMTEWIQ QNNILSIVLQ DSLHQPQYVE KIEKILRFVI 420
KEKALTLQDL NNIWAAQAGK HEAIVKNVHD LLAKLAWNFS PEQLDHLFDC FKASWTNASK 480
KQREKLLELI RRLAEDDKDG VMAHKVLNLL WNLAHSDDVP VDIMDLALSA HIKILDYSCS 540
QDRDTQKIQW IDCFIEEFRT NNKWVIPALK QIKEICSLFG EAPQNLSQTH QSPRVFYRHD 600
LISQLQHNHA LVTLVAENLA AYMNSIRLYA RDHEDYDPQT VRLGSRYSHV QEVQERLNFL 660
RFLLKDGQLW LCVSQAKQIW NCLAENAVYF SDREACFMWY SKLMGDEPDL HPDINKEFFE 720
SNVLQLDPSL LTENGMKCFE RFFKTVNCRE GKLMIKRKIY MMDDLDLIGL DYLWKVVIQS 780
NDDISSRAID LLKEIYTSLG PKLQANQVVI HEDFIQSCFD RLKASYDTLC VLDSEKDNIF 840
SCARQEAIRM VRILTVLREY ISEYDSDYHE ERMILPMSRA FRGKHLSFTV RFPNQGKEVE 900
DLDILSHTNA TIGSVRRCIL NRMNVNVAHT KIELFIGGEL VASEDDRKLV EQLNLKDKSL 960
ITAKFIQINS NMPSSPDSSS DSSAGPPGNH SHNNYRDVSN PEMEKCLPGV IMSLQPRYIS 1020
FLWQVADLGS MLTVPTLRDG ARILMKLMPP DSTTLEQLRA LCSDHVNLGE RRLGQSLHSL 1080
FFGSSASQVL YLTEVVYTLL MPAGAPLADI SSDFQYHFLK SGGLPLVLSM LIQNNFLPNT 1140
DVETRRDAYF SALKIAKLLL TIVGYGHVQA IAEACQPVAD GTDPKTPINQ VTHDQAVVLQ 1200
NALQSIPNPS SECMLRNVSV HLAQQISGLA SRYIPDICVI RAIQKIIWAA GCGSLELVFS 1260
PNEDITETYK MTTSTRSNLE VKDEQVCCEA LEVMTLCFAL IPTAMDSLNK EKAWQSFVID 1320
LLLYCPSKTV RQLAQEQFFL ICTRCCMGHR PLLFFITLLF TILGGAANEK GKHSDVYFTL 1380
LRRLLTYAYN SNIQVPNVDV LLNDEIDWLK RVRDYIKNTG ETNVEDPILE GHLGVTKELL 1440
SFQSPEKKYH IGCKTGGANL VKELIDYFIF PASKAYLQYM RSGELPIKQA IPVCGSPATI 1500
NAGFELLVAL AFGCVRNLKQ IVNCLTELFY IGTPVTTCEA VGEWEYLPPV GPRPPKGFVG 1560
LKNAGATCYM NSVIQQLYMI PSIRNSILAI DSIWSDTDDD IFKGEKQDSE NNVDPRDDVF 1620
RYPHQFEDKP TLSKVEDRKE YNIAVLKHLQ ITFGHLAASQ LQYYVPKGFW QQFRLWGEPV 1680
NLREQHDALE FFNSLVDSLD EAFKALGYPT VLSKVLGGSF ADQKICQGCP HRYECEESFT 1740
TLNVDIRNHQ NLLDSLEQYV KGDLLEGANA YHCEKCDKKV DTVKRLLIKK LPSVLTIQLK 1800
RFDYDWEREC AIKFNDYFEF PRELDMEPYT VAGATKLEGD SVNPQTQLIK QNEQSESVIP 1860
GSTKYRLVGV LVHSGQANGG HYYSYIIQRN GKDSKRSHWF KFDDGDVTEC KMDDDEEMKN 1920
QCFGGEYMGE VFDHMMKRMS YRRQKRWWNA YILFYERMDI TDEDDEIITY ISELTFTRPH 1980
QIMSPAIERS VWKQNVQFLH NQMQFSLEYF QFIKKLLTCN AVYLSPAPGQ DHLLPEAEDI 2040
TMISIQLASR FLFTTGFHTK KIIRGPANDW YDALCILLRH SKNVRFWFVH NVLFNVSNRF 2100
SEYLLECPSA EIRGTFAKLI VFIAHFSLQD GSSPSPFTSP FANPGPYSQI YDNLSLSDHL 2160
LKAVLSLLRR EVSEHGRHLQ QYFNLFIMYA SLGLAEKTQL LKLNVPATFM LVSLDEGPGP 2220
PVKYQYAELS KLHSVVSQLI RCCSVSSRMQ SSINGNPPLP NPFGDPNLSQ PIMPIQQNVA 2280
DILFMRTTYM KKVIEDCSNS EDTVKLLLFC CWENPQFSCS VLSELLWQVA HSHAYELQPY 2340
LDLLLQIILF EDSWQAHRIH NALKGIPNDQ DGLFDTIQHS KNHHQKRAYQ CIKWMVTLFN 2400
SCPVAYQILQ GNGDLKNKWT WAMEWLGDEL ERKPYSGNPQ YTYSNWSPPV QSNETANGYF 2460
LEKSHSAKMK LTKACDLYPE EDPDDQDALD EHVSHAPQDR TFYLYSHRSH YQQNYVPEQP 2520
FSGPASHHLN NPQKNDKPQE THESNEEISS CLIKDQ 2556 
Gene Ontology
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19. 
Pfam
 PF00443; UCH 
SMART
  
PROSITE
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS