CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021290
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vacuolar protein sorting-associated protein 16 homolog 
Protein Synonyms/Alias
 hVPS16 
Gene Name
 VPS16 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
163SANVGDLKLRRMPEVubiquitination[1]
366VARAINQKLGDTPGVubiquitination[1]
393GRTELAIKLLEYEPRubiquitination[1]
516TAADAFYKAKNEFAAubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. 
Sequence Annotation
 MOD_RES 4 4 Nitrated tyrosine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Endosome; Lysosome; Membrane; Nitration; Polymorphism; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 839 AA 
Protein Sequence
MDCYTANWNP LGDSAFYRKY ELYSMDWDLK EELRDCLVAA APYGGPIALL RNPWRKEKAA 60
SVRPVLDIYS ASGMPLASLL WKSGPVVSLG WSAEEELLCV QEDGAVLVYG LHGDFRRHFS 120
MGNEVLQNRV LDARIFHTEF GSGVAILTGA HRFTLSANVG DLKLRRMPEV PGLQSAPSCW 180
TVLCQDRVAH ILLAVGPDLY LLDHAACSAV TPPGLAPGVS SFLQMAVSFT YRHLALFTDT 240
GYIWMGTASL KEKLCEFNCN IRAPPKQMVW CSRPRSKERA VVVAWERRLM VVGDAPESIQ 300
YKQLTIQVLL DRLVLRRLYP LAIQICEYLR LPEVQGVSRI LAHWACYKVQ QKDVSDEDVA 360
RAINQKLGDT PGVSYSDIAA RAYGCGRTEL AIKLLEYEPR SGEQVPLLLK MKRSKLALSK 420
AIESGDTDLV FTVLLHLKNE LNRGDFFMTL RNQPMALSLY RQFCKHQELE TLKDLYNQDD 480
NHQELGSFHI RASYAAEERI EGRVAALQTA ADAFYKAKNE FAAKATEDQM RLLRLQRRLE 540
DELGGQFLDL SLHDTVTTLI LGGHNKRAEQ LARDFRIPDK RLWWLKLTAL ADLEDWEELE 600
KFSKSKKSPI GYLPFVEICM KQHNKYEAKK YASRVGPEQK VKALLLVGDV AQAADVAIEH 660
RNEAELSLVL SHCTGATDGA TADKIQRARA QAQKK 695 
Gene Ontology
 GO:0005884; C:actin filament; IEA:Compara.
 GO:0030424; C:axon; IEA:Compara.
 GO:0005769; C:early endosome; IDA:UniProtKB.
 GO:0030897; C:HOPS complex; IDA:UniProtKB.
 GO:0005770; C:late endosome; IDA:UniProtKB.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0055037; C:recycling endosome; IDA:UniProtKB.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR016534; VPS16.
 IPR006925; Vps16_C.
 IPR006926; Vps16_N. 
Pfam
 PF04840; Vps16_C
 PF04841; Vps16_N 
SMART
  
PROSITE
  
PRINTS