UniProt Accession

 ZNHI3_HUMAN; Q15649; A8K493; Q8WVJ3 

Genbank Protein ID

 AF400652; AK290858; CH471199; BC017931; L40410 

Genbank Nucleotide ID

 AAM82423.1; BAF83547.1; EAW57552.1; AAH17931.1; AAC41737.1 

Protein Name

 Zinc finger HIT domain-containing protein 3 

Protein Synonyms/Alias

 HNF-4a coactivator; Thyroid hormone receptor interactor 3; Thyroid receptor-interacting protein 3; TR-interacting protein 3; TRIP-3 

Gene Name

 ZNHIT3 

Gene Synonyms/Alias

 TRIP3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	RVSLQNLKNLGESAT	ubiquitination	[1, 2]
123	NLDQGEDKAKLMRAY	ubiquitination	[1, 2, 3]
125	DQGEDKAKLMRAYMQ	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 ZN_FING 11 42 HIT-type.
 MOD_RES 80 80 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 155 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; NAS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0046966; F:thyroid hormone receptor binding; TAS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; TAS:UniProtKB. 

Interpro

 IPR007529; Znf_HIT. 

Pfam

 PF04438; zf-HIT 

SMART

  

PROSITE

 PS51083; ZF_HIT 

PRINTS