CPLM-000229

Genbank Nucleotide ID

Lipid phosphate phosphohydrolase 3

Protein Synonyms/Alias

PAP2-beta; Phosphatidate phosphohydrolase type 2b; Phosphatidic acid phosphatase 2b; PAP-2b; PAP2b; Vascular endothelial growth factor and type I collagen-inducible protein; VCIP

Homo sapiens (Human)

Position	Peptide	Type	References
15	KAIVPESKNGGSPAL	ubiquitination	[1, 2, 3]
293	LPAPAIRKEILSPVD	ubiquitination	[1]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[2] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
[3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]

Functional Description

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.

MOD_RES 19 19 Phosphoserine.
MOD_RES 297 297 Phosphoserine.
CARBOHYD 170 170 N-linked (GlcNAc...) (Potential).

Cell membrane; Complete proteome; Glycoprotein; Golgi apparatus; Hydrolase; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005912; C:adherens junction; TAS:BHF-UCL.
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0042577; F:lipid phosphatase activity; IEA:Compara.
GO:0008195; F:phosphatidate phosphatase activity; IEA:EC.
GO:0004721; F:phosphoprotein phosphatase activity; TAS:ProtInc.
GO:0001568; P:blood vessel development; IEA:Compara.
GO:0044329; P:canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion; IMP:BHF-UCL.
GO:0044328; P:canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration; IMP:BHF-UCL.
GO:0044330; P:canonical Wnt receptor signaling pathway involved in positive regulation of wound healing; IMP:BHF-UCL.
GO:0001702; P:gastrulation with mouth forming second; IEA:Compara.
GO:0008354; P:germ cell migration; TAS:ProtInc.
GO:0034109; P:homotypic cell-cell adhesion; IDA:BHF-UCL.
GO:0001933; P:negative regulation of protein phosphorylation; IDA:BHF-UCL.
GO:0006644; P:phospholipid metabolic process; IEA:Compara.
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Compara.
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
GO:0050821; P:protein stabilization; IDA:BHF-UCL.
GO:0030111; P:regulation of Wnt receptor signaling pathway; IEA:Compara.
GO:0044281; P:small molecule metabolic process; TAS:Reactome.
GO:0030148; P:sphingolipid biosynthetic process; TAS:Reactome.

IPR016118; P_Acid_Pase/Cl_peroxidase_N.
IPR000326; P_Acid_Pase_2/haloperoxidase.